An opioid-based pain control program for head and neck cancer patients undergoing chemoradiation therapy achieves a high completion rate of radiation

Kengo Kato, Kazuto Matsuura, Sadamoto Zenda, Hiroyuki Tachibana, Akihiro Homma, Tadaaki Kirita, Nobuya Monden, Yojiro Ota, Shigemichi Iwae, Hiroshi Otsuru, Tetsuo Akimoto, Makoto Tahara, Masao Asai

Research output: Contribution to journalArticle

Abstract

Background: Appropriate supportive care is essential for intensive chemoradiation therapy (CRT), and pain management is an important supportive care for CRT for head and neck cancer. We developed an opioid-based pain control program for head and neck cancer patients undergoing CRT, and assessed its efficacy and safety. Objective and Method: 110 head and neck cancer patients undergoing platinum-based concomitant CRT were enrolled from 10 cancer centers or university hospitals. Their pain caused by CRT was managed with a four-step opioid-based pain control program, and adverse events and usage of opioid were analyzed. Results: 101 suitable cases of 110 patients were analyzed. 53% of cases suffered grade 3-4 mucositis. The rate of completion of radiotherapy was 99% and the rate of unplanned breaks in radiotherapy was 13%. The usage rate of opioid was 83% and the rate of compliance with the pain control program was 92%. The median maximum quantity of morphine used per day was 35 mg. No patient had to stop the opioid program or radiotherapy due to adverse effects of opioids. Conclusion: An opioid-based pain control program for head and neck cancer patients undergoing CRT achieves a high completion rate of radiation.

Original languageEnglish
Pages (from-to)153-157
Number of pages5
JournalJapanese Journal of Head and Neck Cancer
Volume37
Issue number1
DOIs
Publication statusPublished - 2011

Keywords

  • Chemoradiation therapy
  • Head and neck cancer
  • PEG
  • Pain management
  • Supportive care

ASJC Scopus subject areas

  • Otorhinolaryngology
  • Oncology

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    Kato, K., Matsuura, K., Zenda, S., Tachibana, H., Homma, A., Kirita, T., Monden, N., Ota, Y., Iwae, S., Otsuru, H., Akimoto, T., Tahara, M., & Asai, M. (2011). An opioid-based pain control program for head and neck cancer patients undergoing chemoradiation therapy achieves a high completion rate of radiation. Japanese Journal of Head and Neck Cancer, 37(1), 153-157. https://doi.org/10.5981/jjhnc.37.153