An operative case of ulcerative colitis associated with hyperthyroidism

Atsushi Kohyama, Yuji Funayama, Kouhei Fukushima, Chikashi Shibata, Koh Miura, Ken Ichi Takahashi, Hitoshi Ogawa, Tatsuya Ueno, Iwao Sasaki, Nobuo Hiwatashi

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1 Citation (Scopus)


We encountered a rare operative case of hyperthyroidism followed by ulcerative colitis (UC). A 26-year-old mam was referred to our department to undergo an operation. We suspected the possible complication of adrenal insufficiency, since he suffered from severe weight loss, a high fever and palpitation on admission. We diagnosed hyperthyroidism, however, based on the presence of high serum free T3 and T4 levels and a decreased TSH level. After improving the symptoms and the thyroid function by administering thiamazole, we then performed a total proctocolectomy. Although a high rate of association of autoimmune thyroid diseases with UC has been suggested, only 9 cases of hyperthyroidism coexisting with UC have so far been reported in Japan. A common immunological process has been suggested to be implicated in the pathogenesis of this association, however, the exact mechanism needs to be elucidated in the future.

Original languageEnglish
Pages (from-to)820-825
Number of pages6
JournalJournal of Japanese Society of Gastroenterology
Issue number6
Publication statusPublished - 2009

ASJC Scopus subject areas

  • Gastroenterology


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