An NDPase links ADAM protease glycosylation with organ morphogenesis in C. elegans

Kiyoji Nishiwaki, Yukihiko Kubota, Yuko Chigira, Samir Kumar Roy, Maho Suzuki, Mara Schvarzstein, Yoshifumi Jigami, Naoki Hisamoto, Kunihiro Matsumoto

    Research output: Contribution to journalArticlepeer-review

    44 Citations (Scopus)

    Abstract

    In the nematode Caenorhabditis elegans, the gonad acquires two U-shaped arms through the directed migration of its distal tip cells (DTCs), which are located at the tip of the growing gonad arms. A member of the ADAM (a disintegrin and metalloprotease) family, MIG-17, regulates directional migration of DTCs: MIG-17 is synthesized and secreted from the muscle cells of the body wall, and diffuses to the gonad where it is required for DTC migration. The mig-23 mutation causes defective migration of DTCs and interacts genetically with mig-17. Here, we report that mig-23 encodes a membrane-bound nucleoside diphosphatase (NDPase) required for glycosylation and proper localization of MIG-17. Our findings indicate that an NDPase affects organ morphogenesis through glycosylation of the MIG-17 ADAM protease.

    Original languageEnglish
    Pages (from-to)31-37
    Number of pages7
    JournalNature cell biology
    Volume6
    Issue number1
    DOIs
    Publication statusPublished - 2004 Jan 1

    ASJC Scopus subject areas

    • Cell Biology

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