An M-CSF receptor c-Fms antibody inhibits mechanical stress-induced root resorption during orthodontic tooth movement in mice

Hideki Kitaura, Yuji Fujimura, Masako Yoshimatsu, Toshiko Eguchi, Haruka Kohara, Insan Jang, Yukiko Morita, Noriaki Yoshida

Research output: Contribution to journalArticlepeer-review

15 Citations (Scopus)

Abstract

To examine the effect of anti-c-Fms antibody on odontoclastogenesis and root resorption in an orthodontic tooth movement mouse model.Materials and Methods: We used orthodontic tooth movement in which an Ni-Ti coil spring was inserted between the upper incisors and the upper first molar. Root resorption occurred in thismodel. Anti-c-Fms antibody was injected daily into a local site for 12 days during mechanicalloading. Odontoclastogenesis and root resorption were assessed by histology and scanning electron microscopy.Results: The anti-c-Fms antibody significantly inhibited odontoclastogenesis and root resorption during orthodontic tooth movement.Conclusion: M-CSF and/or its receptor is a potential therapeutic target in mechanical stress-induced odontoclastogenesis, and injection of an anti-c-Fms antibody might be useful for inhibitionof mechanical stress-induced root resorption during orthodontic tooth movement. (Angle Orthod.2009;79:835-841.

Original languageEnglish
Pages (from-to)835-841
Number of pages7
JournalAngle Orthodontist
Volume79
Issue number5
DOIs
Publication statusPublished - 2009 Sep
Externally publishedYes

Keywords

  • -Fms
  • Mouse
  • Odontoclast
  • Orthodontics
  • Root resorption

ASJC Scopus subject areas

  • Orthodontics

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