An LD50 model for predicting psychotropic drug toxicity using biopartitioning micellar chromatography

Makoto Tsunoda, Kazuko Takezawa, Teruyuki Yanagisawa, Masaru Kato, Kazuhiro Imai

Research output: Contribution to journalArticlepeer-review

19 Citations (Scopus)


The LD50 determination is the main way to measure the acute toxicity of all types of substances. At the present time, however, there is increasing opposition to the use of living animals in research and testing activities from animal rights groups as well as some scientists. Nevertheless, the need to have a tool for estimating the potential toxicity of new compounds for human consumption has encouraged the development of alternative methods. Under adequate conditions, the partitioning in micellar liquid chromatography can describe the drug biopartitioning. We have named this chromatographic system biopartitioning micellar chromatography (BMC). In this paper, an LD50 QRAR model developed for psychotropic drugs from their retention data in BMC, is described. The model's ability to predict new psychotropic drug toxicity is statistically proved.

Original languageEnglish
Pages (from-to)31-40
Number of pages10
JournalBiomedical Chromatography
Issue number1
Publication statusPublished - 2001

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry
  • Molecular Biology
  • Pharmacology
  • Drug Discovery
  • Clinical Biochemistry

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