An immunohistochemical study on pulmonary surfactant of infants diagnosed as sudden infant death syndrome

M. Funayama, N. Kageyama, S. Ohtani, S. Tokudome, N. Tabata, M. Morita

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Pulmonary tissues from 22 autopsy cases diagnosed as sudden infant death syndrome (SIDS) were examined by immunoperoxidase method using monoclonal antibodies against human pulmonary surfactant apoproteins. In all cases except one, a moderate or large amount of pulmonary surfactant existed in the alveolar spaces. In the cytoplasm of the alveolar type II cells of most cases, a variable number of reaction products were also recognized. This study suggested that SIDS babies suffered lethal hypoxic state, but the staining intensity of pulmonary surfactant did not show a clear difference in sleeping positions.

Original languageEnglish
Pages (from-to)225-230
Number of pages6
JournalJapanese Journal of Legal Medicine
Volume48
Issue number4
Publication statusPublished - 1994 Jan 1
Externally publishedYes

Keywords

  • hypoxia
  • immunohistochemical study
  • pulmonary surfactant
  • sleeping position
  • sudden infant death syndrome

ASJC Scopus subject areas

  • Health Policy
  • Law

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