The present study investigated the localization of biglycan, decorin and large chondroitin-sulphate proteoglycans (versican) in 32 cases of pleomorphic adenoma (PA) by immunohistochemical staining. The neoplastic epithelium of PA showed wide staining for versican and biglycan. Myxomatous and chondroid tissues showed restricted staining for versican and biglycan. The intense staining for decorin was observed in fibrous connective tissue of the capsule, whereas only one case in the present study showed the positive staining for decorin in the mesenchymal tissues of PA. These results indicated that both biglycan and versican might be involved in, at least in part, the morphogenesis of neoplastic epithelium and mesenchymal tissues in PA.
- Pleomorphic adenoma
- Salivary gland
ASJC Scopus subject areas
- Pathology and Forensic Medicine
- Cell Biology