An immunohistochemical study of the localization of biglycan, decorin and large chondroitin-sulphate proteoglycan in pleomorphic adenoma

Yoshihiro Abiko, Michiko Nishimura, Jiro Mitamura, Firoz Rahemtulla, Paul G. Scott, Carole M. Dodd, Itaru Mizoguchi, Tohru Kaku

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

The present study investigated the localization of biglycan, decorin and large chondroitin-sulphate proteoglycans (versican) in 32 cases of pleomorphic adenoma (PA) by immunohistochemical staining. The neoplastic epithelium of PA showed wide staining for versican and biglycan. Myxomatous and chondroid tissues showed restricted staining for versican and biglycan. The intense staining for decorin was observed in fibrous connective tissue of the capsule, whereas only one case in the present study showed the positive staining for decorin in the mesenchymal tissues of PA. These results indicated that both biglycan and versican might be involved in, at least in part, the morphogenesis of neoplastic epithelium and mesenchymal tissues in PA.

Original languageEnglish
Pages (from-to)459-463
Number of pages5
JournalACTA HISTOCHEMICA ET CYTOCHEMICA
Volume32
Issue number6
DOIs
Publication statusPublished - 1999 Jan 1
Externally publishedYes

Keywords

  • Biglycan
  • Immunohistochemistry
  • PG-M/Versican
  • Pleomorphic adenoma
  • Salivary gland

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Biochemistry
  • Physiology
  • Histology
  • Cell Biology

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