An experimental study on O-[ 18F]fluoromethyl-L-tyrosine for differentiation between tumor and inflammatory tissues

Manami Suzuki, Keiichiro Yamaguchi, Go Honda, Ren Iwata, Shozo Furumoto, Myeong Gi Jeong, Hiroshi Fukuda, Masatoshi Itoh

Research output: Contribution to journalArticlepeer-review

12 Citations (Scopus)

Abstract

Objective: O-[ 18F]fluoromethyl-L-tyrosine ( 18F-FMT) is a recently developed tumor-detecting agent with simple preparation and high radiochemical yields. The aim of this study was to assess the potency of 18F-FMT for differentiating tumor and inflammatory tissues using an animal model with an implanted tumor and experimentally induced inflammatory foci. Methods: An ascites hepatoma cell line, AH109A, turpentine oil and Staphylococcus aureus were inoculated subcutaneously into Donryu rats as a tumor model, aseptic inflammation model and bacterial infection model, respectively. The biodistribution of radioactivity was assessed in rats at 5, 10, 30, 60, and 120 min after injection with 18F-FMT. Dual tracer whole-body and macro autoradiographies were performed 60 min after injection with a mixture of 18F-FMT and 2-deoxy-D-[1- 14C]glucose ( 14CDG). Results: Tumor uptake of 18F-FMT was on average 1.27% injected dose per gram of tissue (%ID/g) and 1.43%ID/g at 30 min and 60 min, respectively and significantly higher than that in other normal tissues, except the pancreas (3.48%ID/g at 60 min). The uptakes in the aseptic and bacterial inflammatory tissues were very low and were not different from those of the background tissues. Dual tracer whole-body and macro autoradiographic studies showed that tumor uptake of 18F-FMT was clearly higher than uptake by the other tissues, while 18F-FMT accumulated much less both in aseptic and bacterial inflammatory tissues. In contrast, the 14C-DG images showed high accumulations not only in tumors but also in aseptic and bacterial inflammatory tissues. Conclusion: 18F-FMT seems to be a promissing tracer for the differentiation between tumor and inflammation because of higher specificity to tumor.

Original languageEnglish
Pages (from-to)589-595
Number of pages7
JournalAnnals of Nuclear Medicine
Volume19
Issue number7
DOIs
Publication statusPublished - 2005

Keywords

  • 2-deoxy-D-[1- C] glucose
  • F-FDG
  • Inflammation
  • O-[ F]fluoromethyl-L-tyrosine
  • Tumor

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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