An experimental study of the therapeutic effect of interleukin-2 and interleukin-12 with and without amphotericin B on pulmonary fungal infection

Chang ran Zhang, Ying chun Tang, K. Kawakami, Tian tuo Zhang, Kou xing Zhang, Jia xin Zhu

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

OBJECTIVE: To study the therapeutic effect of interleukin-2 (IL-2) and interleukin-12 (IL-12) with and without amphotericin B on pulmonary fungal infection of mice. METHODS: A mouse model of pulmonary invasive aspergillus fumigatus (IPA) infection was established and the mice were divided into different groups, treated with IL-2 and IL-12 with and without amphotericin B. The survival number of mice in 15 days and the colony count of lung tissue in the different groups were observed. RESULTS: IL-2, IL-12 and amphotericin B showed synergistic effect in prolonging the survival of the infected mice and reducing the colony count in the lung tissue. CONCLUSION: IL-2 and IL-12 are effective adjuvant therapeutic agents in the immunosuppressed hosts.

Original languageEnglish
Pages (from-to)234-236
Number of pages3
JournalZhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases
Volume27
Issue number4
Publication statusPublished - 2004 Apr
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)

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