An expeditious chemo-enzymatic route from glucose to catechol by theuse of 2-deoxy-scyllo-inosose synthase

Katsumi Kakinuma; Eriko Nango; Fumitaka Kudo; Yoshitaka Matsushima; Tadashi Eguchi

doi:10.1016/S0040-4039(00)00064-2

An expeditious chemo-enzymatic route from glucose to catechol by theuse of 2-deoxy-scyllo-inosose synthase

Katsumi Kakinuma, Eriko Nango, Fumitaka Kudo, Yoshitaka Matsushima, Tadashi Eguchi

Research output: Contribution to journal › Article › peer-review

29 Citations (Scopus)

Abstract

A potential two-step process to catechol from D-glucose comprising one- pot incubation of D-glucose with recombinant 2-deoxy-scyllo-inosose synthase (BtrC) and hexokinase, togther with chemical reductive dehydration of the resulting 2-deoxy-scyllo-inosose with Hl, was developed. (C) 2000 Elsevier Science Ltd.

Original language	English
Pages (from-to)	1935-1938
Number of pages	4
Journal	Tetrahedron Letters
Volume	41
Issue number	12
DOIs	https://doi.org/10.1016/S0040-4039(00)00064-2
Publication status	Published - 2000 Mar 18
Externally published	Yes

Keywords

Carbocycle forming enzyme
Catechol
Chemo-enzymatic route
Glucose

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

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10.1016/S0040-4039(00)00064-2

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abstract = "A potential two-step process to catechol from D-glucose comprising one- pot incubation of D-glucose with recombinant 2-deoxy-scyllo-inosose synthase (BtrC) and hexokinase, togther with chemical reductive dehydration of the resulting 2-deoxy-scyllo-inosose with Hl, was developed. (C) 2000 Elsevier Science Ltd.",

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AU - Kakinuma, Katsumi

AU - Nango, Eriko

AU - Kudo, Fumitaka

AU - Matsushima, Yoshitaka

AU - Eguchi, Tadashi

N1 - Funding Information: This work was financially supported by the Research for the Future Program of the Japan Society for the Promotion of Science (JSPS-RFTF96I00302) and a Grant-in-Aid for Scientific Research (11356004) from the Ministry of Education, Science, Sports and Culture.

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N2 - A potential two-step process to catechol from D-glucose comprising one- pot incubation of D-glucose with recombinant 2-deoxy-scyllo-inosose synthase (BtrC) and hexokinase, togther with chemical reductive dehydration of the resulting 2-deoxy-scyllo-inosose with Hl, was developed. (C) 2000 Elsevier Science Ltd.

AB - A potential two-step process to catechol from D-glucose comprising one- pot incubation of D-glucose with recombinant 2-deoxy-scyllo-inosose synthase (BtrC) and hexokinase, togther with chemical reductive dehydration of the resulting 2-deoxy-scyllo-inosose with Hl, was developed. (C) 2000 Elsevier Science Ltd.

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KW - Chemo-enzymatic route

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An expeditious chemo-enzymatic route from glucose to catechol by theuse of 2-deoxy-scyllo-inosose synthase

Abstract

Keywords

ASJC Scopus subject areas

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