An expeditious chemo-enzymatic route from glucose to catechol by theuse of 2-deoxy-scyllo-inosose synthase

Katsumi Kakinuma, Eriko Nango, Fumitaka Kudo, Yoshitaka Matsushima, Tadashi Eguchi

Research output: Contribution to journalArticlepeer-review

27 Citations (Scopus)

Abstract

A potential two-step process to catechol from D-glucose comprising one- pot incubation of D-glucose with recombinant 2-deoxy-scyllo-inosose synthase (BtrC) and hexokinase, togther with chemical reductive dehydration of the resulting 2-deoxy-scyllo-inosose with Hl, was developed. (C) 2000 Elsevier Science Ltd.

Original languageEnglish
Pages (from-to)1935-1938
Number of pages4
JournalTetrahedron Letters
Volume41
Issue number12
DOIs
Publication statusPublished - 2000 Mar 18
Externally publishedYes

Keywords

  • Carbocycle forming enzyme
  • Catechol
  • Chemo-enzymatic route
  • Glucose

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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