An expedient route to a potent gastrin/CCK-B receptor antagonist (+)-AG-041R

Shigeki Sato; Masatoshi Shibuya; Naoki Kanoh; Yoshiharu Iwabuchi

doi:10.1021/jo901352u

An expedient route to a potent gastrin/CCK-B receptor antagonist (+)-AG-041R

Shigeki Sato, Masatoshi Shibuya, Naoki Kanoh, Yoshiharu Iwabuchi

PHA - Molecular Pharmaceutical Science

Research output: Contribution to journal › Article › peer-review

47 Citations (Scopus)

Abstract

(Chemical Equation Presented) An enantiocontrolled synthesis of (+)-AG-041R (1), a potent gastrin/CCK-B receptor antagonist, has been achieved employing a chiral rhodium(II)-catalyzed, oxidative intramolecular aza-spiroannulation as the key step.

Original language	English
Pages (from-to)	7522-7524
Number of pages	3
Journal	Journal of Organic Chemistry
Volume	74
Issue number	19
DOIs	https://doi.org/10.1021/jo901352u
Publication status	Published - 2009 Oct 2

ASJC Scopus subject areas

Organic Chemistry

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title = "An expedient route to a potent gastrin/CCK-B receptor antagonist (+)-AG-041R",

abstract = "(Chemical Equation Presented) An enantiocontrolled synthesis of (+)-AG-041R (1), a potent gastrin/CCK-B receptor antagonist, has been achieved employing a chiral rhodium(II)-catalyzed, oxidative intramolecular aza-spiroannulation as the key step.",

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AU - Sato, Shigeki

AU - Shibuya, Masatoshi

AU - Kanoh, Naoki

AU - Iwabuchi, Yoshiharu

PY - 2009/10/2

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N2 - (Chemical Equation Presented) An enantiocontrolled synthesis of (+)-AG-041R (1), a potent gastrin/CCK-B receptor antagonist, has been achieved employing a chiral rhodium(II)-catalyzed, oxidative intramolecular aza-spiroannulation as the key step.

AB - (Chemical Equation Presented) An enantiocontrolled synthesis of (+)-AG-041R (1), a potent gastrin/CCK-B receptor antagonist, has been achieved employing a chiral rhodium(II)-catalyzed, oxidative intramolecular aza-spiroannulation as the key step.

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JF - Journal of Organic Chemistry

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An expedient route to a potent gastrin/CCK-B receptor antagonist (+)-AG-041R

Abstract

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