An epidemiological study of malformations in infants delivered from diabetic mothers

M. Tanabe, A. Morita, Y. Kusaka, M. Iki, K. Sato, N. Toyoda, T. Sugiyama, T. Deguchi

Research output: Contribution to journalArticlepeer-review


The purpose of this study is to investigate the risks of delivery of malformed infants in diabetic mothers in comparison with those in non- diabetic mothers and to clarify risk factors for malformation due to maternal diabetes. The delivery records available at the Department of Obstetrics and Gynecology, Mie University School of Medicine between 1979 and 1992 showed 103 mothers with diabetes mellitus among 4,353 pregnancies. The incidence of malformation in infants born to diabetic mothers was 9.7% and it was 2.5% overall. By logistic regression analysis of all mothers in this series, diabetes as well as maternal age, and fetal age were shown to be significant risk factors for malformation. A further logistic model for diabetic mothers revealed that a younger age of the mother at the time of labour, low fetal age, older age at onset of diabetes, previous history of pregnancies, and an Hemoglobin A1 (HbA1) level higher than 9% were independent risk factors, among which HbA1 (>9%) showed the highest odds ratio of 24. Careful management is therefore needed to reduce the risk of malformation in pregnancy of diabetic mothers.

Original languageEnglish
Pages (from-to)103-110
Number of pages8
JournalActa Obstetrica et Gynaecologica Japonica
Issue number2
Publication statusPublished - 1996
Externally publishedYes


  • Diabetes mellitus
  • Epidemiology
  • HbA
  • Malformation
  • Risk factor

ASJC Scopus subject areas

  • Obstetrics and Gynaecology


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