An enzyme logic bioprotonic transducer

Takeo Miyake, Erik E. Josberger, Scott Keene, Yingxin Deng, Marco Rolandi

    Research output: Contribution to journalArticlepeer-review

    33 Citations (Scopus)


    Translating ionic currents into measureable electronic signals is essential for the integration of bioelectronic devices with biological systems. We demonstrate the use of a Pd/PdHx electrode as a bioprotonic transducer that connects H+ currents in solution into an electronic signal. This transducer exploits the reversible formation of PdHx in solution according to PdH虠Pd + H+ + e-, and the dependence of this formation on solution pH and applied potential. We integrate the protonic transducer with glucose dehydrogenase as an enzymatic and gate for glucose and NAD+. PdHx formation and associated electronic current monitors the output drop in pH, thus transducing a biological function into a measurable electronic output.

    Original languageEnglish
    Article number014906
    JournalAPL Materials
    Issue number1
    Publication statusPublished - 2015 Jan 1

    ASJC Scopus subject areas

    • Materials Science(all)
    • Engineering(all)


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