An environmentally friendly synthetic method of 1,2-dihydroisoquinoline frameworks via three-component reaction with o-alkynylbenzaldehydes, primary amines, and pronucleophiles

Naoki Asao; Kentaro Iso; S. Salprima Yudha

doi:10.1021/ol0618104

An environmentally friendly synthetic method of 1,2-dihydroisoquinoline frameworks via three-component reaction with o-alkynylbenzaldehydes, primary amines, and pronucleophiles

Naoki Asao, Kentaro Iso, S. Salprima Yudha

Research output: Contribution to journal › Article › peer-review

105 Citations (Scopus)

Abstract

Three-component reactions with ortho-alkynylbenzaldehydes, primary amines, and pronucleophiles (Nu-H), such as CHCl₃, proceeded to give 1,2-dihydroisoquinoline derivatives in good to high yields in the absence of any catalysts under mild reaction conditions.

Original language	English
Pages (from-to)	4149-4151
Number of pages	3
Journal	Organic letters
Volume	8
Issue number	18
DOIs	https://doi.org/10.1021/ol0618104
Publication status	Published - 2006 Aug 31

ASJC Scopus subject areas

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

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abstract = "Three-component reactions with ortho-alkynylbenzaldehydes, primary amines, and pronucleophiles (Nu-H), such as CHCl3, proceeded to give 1,2-dihydroisoquinoline derivatives in good to high yields in the absence of any catalysts under mild reaction conditions.",

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AU - Iso, Kentaro

AU - Yudha, S. Salprima

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AB - Three-component reactions with ortho-alkynylbenzaldehydes, primary amines, and pronucleophiles (Nu-H), such as CHCl3, proceeded to give 1,2-dihydroisoquinoline derivatives in good to high yields in the absence of any catalysts under mild reaction conditions.

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An environmentally friendly synthetic method of 1,2-dihydroisoquinoline frameworks via three-component reaction with o-alkynylbenzaldehydes, primary amines, and pronucleophiles

Abstract

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