An environmentally friendly synthetic method of 1,2-dihydroisoquinoline frameworks via three-component reaction with o-alkynylbenzaldehydes, primary amines, and pronucleophiles

Naoki Asao, Kentaro Iso, S. Salprima Yudha

    Research output: Contribution to journalArticlepeer-review

    105 Citations (Scopus)

    Abstract

    Three-component reactions with ortho-alkynylbenzaldehydes, primary amines, and pronucleophiles (Nu-H), such as CHCl3, proceeded to give 1,2-dihydroisoquinoline derivatives in good to high yields in the absence of any catalysts under mild reaction conditions.

    Original languageEnglish
    Pages (from-to)4149-4151
    Number of pages3
    JournalOrganic letters
    Volume8
    Issue number18
    DOIs
    Publication statusPublished - 2006 Aug 31

    ASJC Scopus subject areas

    • Biochemistry
    • Physical and Theoretical Chemistry
    • Organic Chemistry

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