An engram found? Evaluating the evidence from fruit flies

Bertram Gerber, Hiromu Tanimoto, Martin Heisenberg

Research output: Contribution to journalReview articlepeer-review

144 Citations (Scopus)

Abstract

Is it possible to localize a memory trace to a subset of cells in the brain? If so, it should be possible to show: first, that neuronal plasticity occurs in these cells. Second, that neuronal plasticity in these cells is sufficient for memory. Third, that neuronal plasticity in these cells is necessary for memory. Fourth, that memory is abolished if these cells cannot provide output during testing. And fifth, that memory is abolished if these cells cannot receive input during training. With regard to olfactory learning in flies, we argue that the notion of the olfactory memory trace being localized to the Kenyon cells of the mushroom bodies is a reasonable working hypothesis.

Original languageEnglish
Pages (from-to)737-744
Number of pages8
JournalCurrent Opinion in Neurobiology
Volume14
Issue number6
DOIs
Publication statusPublished - 2004 Dec
Externally publishedYes

ASJC Scopus subject areas

  • Neuroscience(all)

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