An enantio- and stereocontrolled route to epopromycin B via cinchona alkaloid-catalyzed Baylis-Hillman reaction

Yoshiharu Iwabuchi, Tatsuya Sugihara, Tomoyuki Esumi, Susumi Hatakeyama

Research output: Contribution to journalArticle

98 Citations (Scopus)

Abstract

An enantio- and stereocontrolled route to epopromycin B having the epoxy-β-aminoketone pharmacophore is developed based on the cinchona alkaloid-catalyzed Baylis-Hillman reaction of N-Fmoc-leucinal.

Original languageEnglish
Pages (from-to)7867-7871
Number of pages5
JournalTetrahedron Letters
Volume42
Issue number44
DOIs
Publication statusPublished - 2001 Oct 29
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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