An enantio- and stereocontrolled route to epopromycin B via cinchona alkaloid-catalyzed Baylis-Hillman reaction

Yoshiharu Iwabuchi; Tatsuya Sugihara; Tomoyuki Esumi; Susumi Hatakeyama

doi:10.1016/S0040-4039(01)01676-8

An enantio- and stereocontrolled route to epopromycin B via cinchona alkaloid-catalyzed Baylis-Hillman reaction

Yoshiharu Iwabuchi, Tatsuya Sugihara, Tomoyuki Esumi, Susumi Hatakeyama

Research output: Contribution to journal › Article › peer-review

100 Citations (Scopus)

Abstract

An enantio- and stereocontrolled route to epopromycin B having the epoxy-β-aminoketone pharmacophore is developed based on the cinchona alkaloid-catalyzed Baylis-Hillman reaction of N-Fmoc-leucinal.

Original language	English
Pages (from-to)	7867-7871
Number of pages	5
Journal	Tetrahedron Letters
Volume	42
Issue number	44
DOIs	https://doi.org/10.1016/S0040-4039(01)01676-8
Publication status	Published - 2001 Oct 29
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

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10.1016/S0040-4039(01)01676-8

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title = "An enantio- and stereocontrolled route to epopromycin B via cinchona alkaloid-catalyzed Baylis-Hillman reaction",

abstract = "An enantio- and stereocontrolled route to epopromycin B having the epoxy-β-aminoketone pharmacophore is developed based on the cinchona alkaloid-catalyzed Baylis-Hillman reaction of N-Fmoc-leucinal.",

author = "Yoshiharu Iwabuchi and Tatsuya Sugihara and Tomoyuki Esumi and Susumi Hatakeyama",

note = "Funding Information: This study received financial support from Uehara Memorial Foundation and Japan Society for the Promotion of Science (Grant-in Aid for Encouragement of Young Scientists). ",

year = "2001",

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T1 - An enantio- and stereocontrolled route to epopromycin B via cinchona alkaloid-catalyzed Baylis-Hillman reaction

AU - Iwabuchi, Yoshiharu

AU - Sugihara, Tatsuya

AU - Esumi, Tomoyuki

AU - Hatakeyama, Susumi

N1 - Funding Information: This study received financial support from Uehara Memorial Foundation and Japan Society for the Promotion of Science (Grant-in Aid for Encouragement of Young Scientists).

PY - 2001/10/29

Y1 - 2001/10/29

N2 - An enantio- and stereocontrolled route to epopromycin B having the epoxy-β-aminoketone pharmacophore is developed based on the cinchona alkaloid-catalyzed Baylis-Hillman reaction of N-Fmoc-leucinal.

AB - An enantio- and stereocontrolled route to epopromycin B having the epoxy-β-aminoketone pharmacophore is developed based on the cinchona alkaloid-catalyzed Baylis-Hillman reaction of N-Fmoc-leucinal.

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U2 - 10.1016/S0040-4039(01)01676-8

DO - 10.1016/S0040-4039(01)01676-8

M3 - Article

AN - SCOPUS:0035968965

VL - 42

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EP - 7871

JO - Tetrahedron Letters

JF - Tetrahedron Letters

SN - 0040-4039

IS - 44

ER -

An enantio- and stereocontrolled route to epopromycin B via cinchona alkaloid-catalyzed Baylis-Hillman reaction

Abstract

ASJC Scopus subject areas

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