An electrically resistive sheet of glial cells for amplifying signals of neuronal extracellular recordings

R. Matsumura, H. Yamamoto, M. Niwano, A. Hirano-Iwata

Research output: Contribution to journalArticlepeer-review

9 Citations (Scopus)

Abstract

Electrical signals of neuronal cells can be recorded non-invasively and with a high degree of temporal resolution using multielectrode arrays (MEAs). However, signals that are recorded with these devices are small, usually 0.01%-0.1% of intracellular recordings. Here, we show that the amplitude of neuronal signals recorded with MEA devices can be amplified by covering neuronal networks with an electrically resistive sheet. The resistive sheet used in this study is a monolayer of glial cells, supportive cells in the brain. The glial cells were grown on a collagen-gel film that is permeable to oxygen and other nutrients. The impedance of the glial sheet was measured by electrochemical impedance spectroscopy, and equivalent circuit simulations were performed to theoretically investigate the effect of covering the neurons with such a resistive sheet. Finally, the effect of the resistive glial sheet was confirmed experimentally, showing a 6-fold increase in neuronal signals. This technique feasibly amplifies signals of MEA recordings.

Original languageEnglish
Article number023701
JournalApplied Physics Letters
Volume108
Issue number2
DOIs
Publication statusPublished - 2016 Jan 11

ASJC Scopus subject areas

  • Physics and Astronomy (miscellaneous)

Fingerprint Dive into the research topics of 'An electrically resistive sheet of glial cells for amplifying signals of neuronal extracellular recordings'. Together they form a unique fingerprint.

Cite this