An efficient synthesis of polymer-supported silyl linkers using a di-Grignard reagent

Takayuki Doi, Masahito Yoshida, Ichiro Hijikuro, Takashi Takahashi

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)

Abstract

Various trialkylsilyl linked polymer supports have been prepared by reacting benzyl chloride resin and a di-Grignard reagent with CuBr·Me2S, followed by dialkylchlorosilanes. 4-Alkoxybenzyl type resin, Wang-Cl 2c and Argogel Wang-Cl 2d provided 4c and 4d at ambient temperature, whereas nonactivated resin, Merrifield 2a and Argogel-Cl 2b afforded 4a and 4b at 60°C. Primary and secondary alcohols 6-10 were attached to the alkyldiisopropyl-linked Wang type resin 4cA by a novel dehydrosilation with B(C6F5)3 as well as by conventional methods.

Original languageEnglish
Pages (from-to)5723-5726
Number of pages4
JournalTetrahedron Letters
Volume45
Issue number29
DOIs
Publication statusPublished - 2004 Jul 12
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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