An efficient synthesis of Nω‐[18F]fluoroacetylserotonin (Nω‐[18F]fluoroacetyl‐5‐hydroxytryptamine)

Masao Tada, Ren Iwata, Hiroshi Sugiyama, Kazunori Sato, Hiroshi Fukuda, Kazuo Kubota, Roko Kubota, Takehiko Fujiwara, Hiromu Takahashi, Akira Wakui, Tatsuo Ido

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    5 Citations (Scopus)

    Abstract

    A rapid synthesis of Nω‐[18F]fluoroacetylserotonin (Nω‐[18F]fluoroacetyl‐5‐hydroxytryptamine) starting from [18F]fluoride and ethyl p‐toluensulfonyloxyacetate is described. The total time required for its synthesis is ca. 90 min. The radiochemical yield, purity, and specific activity (end of bombardment) of the desired hormone are 13.5%, >98%, and 600 mCi/μmol, respectively.

    Original languageEnglish
    Pages (from-to)741-746
    Number of pages6
    JournalJournal of Labelled Compounds and Radiopharmaceuticals
    Volume34
    Issue number8
    DOIs
    Publication statusPublished - 1994 Jan 1

    Keywords

    • N‐[F] fluoroacetyl‐5‐hydroxytryptamine
    • N‐[F]Fluoroacetylserotonin
    • N‐fluoroacetylserotonin
    • [F] fluoride
    • ethyl p‐toluenesulfonyloxyacetate

    ASJC Scopus subject areas

    • Analytical Chemistry
    • Biochemistry
    • Radiology Nuclear Medicine and imaging
    • Drug Discovery
    • Spectroscopy
    • Organic Chemistry

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