An efficient synthesis of 2,6-disubstituted 2,3-dihydro-4 h -pyran-4-ones via sonogashira coupling of p -toluenethiol esters

Haruhiko Fuwa, Seiji Matsukida, Makoto Sasaki

    Research output: Contribution to journalArticlepeer-review

    15 Citations (Scopus)

    Abstract

    An efficient strategy for the synthesis of 2,6-disubstituted 2,3-dihydro-4H-pyran-4-ones has been developed, which relied on Sonogashira coupling of alkynes and p-toluenethiol esters and AgOTf-promoted 6-endo-dig cyclization of the derived -hydroxy ynones.

    Original languageEnglish
    Article numberU01010ST
    Pages (from-to)1239-1242
    Number of pages4
    JournalSynlett
    Issue number8
    DOIs
    Publication statusPublished - 2010 May 14

    Keywords

    • Cross-coupling
    • Cyclization
    • Dihydropyrans
    • Heterocycles
    • Palladium

    ASJC Scopus subject areas

    • Organic Chemistry

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