An efficient synthesis of 2,6-disubstituted 2,3-dihydro-4 h -pyran-4-ones via sonogashira coupling of p -toluenethiol esters

Haruhiko Fuwa; Seiji Matsukida; Makoto Sasaki

doi:10.1055/s-0029-1219794

An efficient synthesis of 2,6-disubstituted 2,3-dihydro-4 h -pyran-4-ones via sonogashira coupling of p -toluenethiol esters

Haruhiko Fuwa, Seiji Matsukida, Makoto Sasaki

Research output: Contribution to journal › Article › peer-review

15 Citations (Scopus)

Abstract

An efficient strategy for the synthesis of 2,6-disubstituted 2,3-dihydro-4H-pyran-4-ones has been developed, which relied on Sonogashira coupling of alkynes and p-toluenethiol esters and AgOTf-promoted 6-endo-dig cyclization of the derived -hydroxy ynones.

Original language	English
Article number	U01010ST
Pages (from-to)	1239-1242
Number of pages	4
Journal	Synlett
Issue number	8
DOIs	https://doi.org/10.1055/s-0029-1219794
Publication status	Published - 2010 May 14

Keywords

Cross-coupling
Cyclization
Dihydropyrans
Heterocycles
Palladium

ASJC Scopus subject areas

Organic Chemistry

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10.1055/s-0029-1219794

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abstract = "An efficient strategy for the synthesis of 2,6-disubstituted 2,3-dihydro-4H-pyran-4-ones has been developed, which relied on Sonogashira coupling of alkynes and p-toluenethiol esters and AgOTf-promoted 6-endo-dig cyclization of the derived -hydroxy ynones.",

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AU - Matsukida, Seiji

AU - Sasaki, Makoto

PY - 2010/5/14

Y1 - 2010/5/14

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AB - An efficient strategy for the synthesis of 2,6-disubstituted 2,3-dihydro-4H-pyran-4-ones has been developed, which relied on Sonogashira coupling of alkynes and p-toluenethiol esters and AgOTf-promoted 6-endo-dig cyclization of the derived -hydroxy ynones.

KW - Cross-coupling

KW - Cyclization

KW - Dihydropyrans

KW - Heterocycles

KW - Palladium

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An efficient synthesis of 2,6-disubstituted 2,3-dihydro-4 h -pyran-4-ones via sonogashira coupling of p -toluenethiol esters

Abstract

Keywords

ASJC Scopus subject areas

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