An efficient synthesis of 2‐ [ carbonyl‐ 11C]acetamido‐2‐deoxy‐D‐glucopyranose (N‐[carbonyl‐11C]acetyl‐D‐glucosamine)

Masao Tada; Atsushi Oikawa; Ren Iwata; Kazunori Sato; Hiroshi Sugiyama; Kazuo Kubota; Kiichi Ishiwata; Hiromu Takahashi; Akira Wakui; Yoshinao Abe; Tatsuo Yamaguchi; Takehiko Fujiwara; Tachio Sato; Tatsuo Ido

doi:10.1002/jlcr.2580290414

An efficient synthesis of 2‐ [ carbonyl‐ ¹¹C]acetamido‐2‐deoxy‐D‐glucopyranose (N‐[carbonyl‐¹¹C]acetyl‐D‐glucosamine)

Masao Tada, Atsushi Oikawa, Ren Iwata, Kazunori Sato, Hiroshi Sugiyama, Kazuo Kubota, Kiichi Ishiwata, Hiromu Takahashi, Akira Wakui, Yoshinao Abe, Tatsuo Yamaguchi, Takehiko Fujiwara, Tachio Sato, Tatsuo Ido

Research output: Contribution to journal › Comment/debate › peer-review

1 Citation (Scopus)

Abstract

A rapid chemical synthesis of 2‐[carbonyl‐¹¹C]acetamido‐2‐deoxy‐D‐glucopyranose (N‐[carbonyl‐¹¹C]acetyl‐D‐glucosamine) starting from [¹¹C]carbon dioxide is described. The total time required for the synthesis, the radiochemical yield, and purity of the titled sugar are ca. 60 min, 49.5% (based on [carbonyl‐¹¹C]acetic acid), and >98%, respectively.

Original language	English
Pages (from-to)	485-490
Number of pages	6
Journal	Journal of Labelled Compounds and Radiopharmaceuticals
Volume	29
Issue number	4
DOIs	https://doi.org/10.1002/jlcr.2580290414
Publication status	Published - 1991 Apr

Keywords

2‐[carbonyl‐C]Acetamido‐2‐deoxy‐D‐glucopyranose
N[carbonyl‐C]acetyl‐D‐glucosamine, [C]carbon dioxide
[carbonyl‐C]acetic acid
chemical synthesis

ASJC Scopus subject areas

Analytical Chemistry
Biochemistry
Radiology Nuclear Medicine and imaging
Drug Discovery
Spectroscopy
Organic Chemistry

Access to Document

10.1002/jlcr.2580290414

Cite this

Tada, M., Oikawa, A., Iwata, R., Sato, K., Sugiyama, H., Kubota, K., Ishiwata, K., Takahashi, H., Wakui, A., Abe, Y., Yamaguchi, T., Fujiwara, T., Sato, T., & Ido, T. (1991). An efficient synthesis of 2‐ [ carbonyl‐ ¹¹C]acetamido‐2‐deoxy‐D‐glucopyranose (N‐[carbonyl‐¹¹C]acetyl‐D‐glucosamine). Journal of Labelled Compounds and Radiopharmaceuticals, 29(4), 485-490. https://doi.org/10.1002/jlcr.2580290414

An efficient synthesis of 2‐ [ carbonyl‐ ¹¹C]acetamido‐2‐deoxy‐D‐glucopyranose (N‐[carbonyl‐¹¹C]acetyl‐D‐glucosamine). / Tada, Masao; Oikawa, Atsushi; Iwata, Ren; Sato, Kazunori; Sugiyama, Hiroshi; Kubota, Kazuo; Ishiwata, Kiichi; Takahashi, Hiromu; Wakui, Akira; Abe, Yoshinao; Yamaguchi, Tatsuo; Fujiwara, Takehiko; Sato, Tachio; Ido, Tatsuo.

In: Journal of Labelled Compounds and Radiopharmaceuticals, Vol. 29, No. 4, 04.1991, p. 485-490.

Research output: Contribution to journal › Comment/debate › peer-review

Tada, M, Oikawa, A, Iwata, R, Sato, K, Sugiyama, H, Kubota, K, Ishiwata, K, Takahashi, H, Wakui, A, Abe, Y, Yamaguchi, T, Fujiwara, T, Sato, T & Ido, T 1991, 'An efficient synthesis of 2‐ [ carbonyl‐ ¹¹C]acetamido‐2‐deoxy‐D‐glucopyranose (N‐[carbonyl‐¹¹C]acetyl‐D‐glucosamine)', Journal of Labelled Compounds and Radiopharmaceuticals, vol. 29, no. 4, pp. 485-490. https://doi.org/10.1002/jlcr.2580290414

Tada, Masao ; Oikawa, Atsushi ; Iwata, Ren ; Sato, Kazunori ; Sugiyama, Hiroshi ; Kubota, Kazuo ; Ishiwata, Kiichi ; Takahashi, Hiromu ; Wakui, Akira ; Abe, Yoshinao ; Yamaguchi, Tatsuo ; Fujiwara, Takehiko ; Sato, Tachio ; Ido, Tatsuo. / An efficient synthesis of 2‐ [ carbonyl‐ ¹¹C]acetamido‐2‐deoxy‐D‐glucopyranose (N‐[carbonyl‐¹¹C]acetyl‐D‐glucosamine). In: Journal of Labelled Compounds and Radiopharmaceuticals. 1991 ; Vol. 29, No. 4. pp. 485-490.

@article{8833d6efc5e64bd1b77bab49ea22cdc6,

title = "An efficient synthesis of 2‐ [ carbonyl‐ 11C]acetamido‐2‐deoxy‐D‐glucopyranose (N‐[carbonyl‐11C]acetyl‐D‐glucosamine)",

abstract = "A rapid chemical synthesis of 2‐[carbonyl‐11C]acetamido‐2‐deoxy‐D‐glucopyranose (N‐[carbonyl‐11C]acetyl‐D‐glucosamine) starting from [11C]carbon dioxide is described. The total time required for the synthesis, the radiochemical yield, and purity of the titled sugar are ca. 60 min, 49.5% (based on [carbonyl‐11C]acetic acid), and >98%, respectively.",

keywords = "2‐[carbonyl‐C]Acetamido‐2‐deoxy‐D‐glucopyranose, N[carbonyl‐C]acetyl‐D‐glucosamine, [C]carbon dioxide, [carbonyl‐C]acetic acid, chemical synthesis",

author = "Masao Tada and Atsushi Oikawa and Ren Iwata and Kazunori Sato and Hiroshi Sugiyama and Kazuo Kubota and Kiichi Ishiwata and Hiromu Takahashi and Akira Wakui and Yoshinao Abe and Tatsuo Yamaguchi and Takehiko Fujiwara and Tachio Sato and Tatsuo Ido",

year = "1991",

month = apr,

doi = "10.1002/jlcr.2580290414",

language = "English",

volume = "29",

pages = "485--490",

journal = "Journal of Labelled Compounds and Radiopharmaceuticals",

issn = "0362-4803",

publisher = "John Wiley and Sons Ltd",

number = "4",

}

TY - JOUR

T1 - An efficient synthesis of 2‐ [ carbonyl‐ 11C]acetamido‐2‐deoxy‐D‐glucopyranose (N‐[carbonyl‐11C]acetyl‐D‐glucosamine)

AU - Tada, Masao

AU - Oikawa, Atsushi

AU - Iwata, Ren

AU - Sato, Kazunori

AU - Sugiyama, Hiroshi

AU - Kubota, Kazuo

AU - Ishiwata, Kiichi

AU - Takahashi, Hiromu

AU - Wakui, Akira

AU - Abe, Yoshinao

AU - Yamaguchi, Tatsuo

AU - Fujiwara, Takehiko

AU - Sato, Tachio

AU - Ido, Tatsuo

PY - 1991/4

Y1 - 1991/4

N2 - A rapid chemical synthesis of 2‐[carbonyl‐11C]acetamido‐2‐deoxy‐D‐glucopyranose (N‐[carbonyl‐11C]acetyl‐D‐glucosamine) starting from [11C]carbon dioxide is described. The total time required for the synthesis, the radiochemical yield, and purity of the titled sugar are ca. 60 min, 49.5% (based on [carbonyl‐11C]acetic acid), and >98%, respectively.

AB - A rapid chemical synthesis of 2‐[carbonyl‐11C]acetamido‐2‐deoxy‐D‐glucopyranose (N‐[carbonyl‐11C]acetyl‐D‐glucosamine) starting from [11C]carbon dioxide is described. The total time required for the synthesis, the radiochemical yield, and purity of the titled sugar are ca. 60 min, 49.5% (based on [carbonyl‐11C]acetic acid), and >98%, respectively.

KW - 2‐[carbonyl‐C]Acetamido‐2‐deoxy‐D‐glucopyranose

KW - N[carbonyl‐C]acetyl‐D‐glucosamine, [C]carbon dioxide

KW - [carbonyl‐C]acetic acid

KW - chemical synthesis

UR - http://www.scopus.com/inward/record.url?scp=0025809145&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025809145&partnerID=8YFLogxK

U2 - 10.1002/jlcr.2580290414

DO - 10.1002/jlcr.2580290414

M3 - Comment/debate

AN - SCOPUS:0025809145

VL - 29

SP - 485

EP - 490

JO - Journal of Labelled Compounds and Radiopharmaceuticals

JF - Journal of Labelled Compounds and Radiopharmaceuticals

SN - 0362-4803

IS - 4

ER -