An efficient synthesis of 2‐ [ carbonyl‐ 11C]acetamido‐2‐deoxy‐D‐glucopyranose (N‐[carbonyl‐11C]acetyl‐D‐glucosamine)

Masao Tada; Atsushi Oikawa; Ren Iwata; Kazunori Sato; Hiroshi Sugiyama; Kazuo Kubota; Kiichi Ishiwata; Hiromu Takahashi; Akira Wakui; Yoshinao Abe; Tatsuo Yamaguchi; Takehiko Fujiwara; Tachio Sato; Tatsuo Ido

doi:10.1002/jlcr.2580290414

An efficient synthesis of 2‐ [ carbonyl‐ ¹¹C]acetamido‐2‐deoxy‐D‐glucopyranose (N‐[carbonyl‐¹¹C]acetyl‐D‐glucosamine)

Masao Tada, Atsushi Oikawa, Ren Iwata, Kazunori Sato, Hiroshi Sugiyama, Kazuo Kubota, Kiichi Ishiwata, Hiromu Takahashi, Akira Wakui, Yoshinao Abe, Tatsuo Yamaguchi, Takehiko Fujiwara, Tachio Sato, Tatsuo Ido

Research output: Contribution to journal › Comment/debate › peer-review

1 Citation (Scopus)

Abstract

A rapid chemical synthesis of 2‐[carbonyl‐¹¹C]acetamido‐2‐deoxy‐D‐glucopyranose (N‐[carbonyl‐¹¹C]acetyl‐D‐glucosamine) starting from [¹¹C]carbon dioxide is described. The total time required for the synthesis, the radiochemical yield, and purity of the titled sugar are ca. 60 min, 49.5% (based on [carbonyl‐¹¹C]acetic acid), and >98%, respectively.

Original language	English
Pages (from-to)	485-490
Number of pages	6
Journal	Journal of Labelled Compounds and Radiopharmaceuticals
Volume	29
Issue number	4
DOIs	https://doi.org/10.1002/jlcr.2580290414
Publication status	Published - 1991 Apr

Keywords

2‐[carbonyl‐C]Acetamido‐2‐deoxy‐D‐glucopyranose
N[carbonyl‐C]acetyl‐D‐glucosamine, [C]carbon dioxide
[carbonyl‐C]acetic acid
chemical synthesis

ASJC Scopus subject areas

Analytical Chemistry
Biochemistry
Radiology Nuclear Medicine and imaging
Drug Discovery
Spectroscopy
Organic Chemistry

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Fingerprint Dive into the research topics of 'An efficient synthesis of 2‐ [ carbonyl‐ <sup>11</sup>C]acetamido‐2‐deoxy‐D‐glucopyranose (N‐[carbonyl‐<sup>11</sup>C]acetyl‐D‐glucosamine)'. Together they form a unique fingerprint.

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Tada, M., Oikawa, A., Iwata, R., Sato, K., Sugiyama, H., Kubota, K., Ishiwata, K., Takahashi, H., Wakui, A., Abe, Y., Yamaguchi, T., Fujiwara, T., Sato, T., & Ido, T. (1991). An efficient synthesis of 2‐ [ carbonyl‐ ¹¹C]acetamido‐2‐deoxy‐D‐glucopyranose (N‐[carbonyl‐¹¹C]acetyl‐D‐glucosamine). Journal of Labelled Compounds and Radiopharmaceuticals, 29(4), 485-490. https://doi.org/10.1002/jlcr.2580290414

An efficient synthesis of 2‐ [ carbonyl‐ ¹¹C]acetamido‐2‐deoxy‐D‐glucopyranose (N‐[carbonyl‐¹¹C]acetyl‐D‐glucosamine). / Tada, Masao; Oikawa, Atsushi; Iwata, Ren; Sato, Kazunori; Sugiyama, Hiroshi; Kubota, Kazuo; Ishiwata, Kiichi; Takahashi, Hiromu; Wakui, Akira; Abe, Yoshinao; Yamaguchi, Tatsuo; Fujiwara, Takehiko; Sato, Tachio; Ido, Tatsuo.

In: Journal of Labelled Compounds and Radiopharmaceuticals, Vol. 29, No. 4, 04.1991, p. 485-490.

Research output: Contribution to journal › Comment/debate › peer-review

Tada, M, Oikawa, A, Iwata, R, Sato, K, Sugiyama, H, Kubota, K, Ishiwata, K, Takahashi, H, Wakui, A, Abe, Y, Yamaguchi, T, Fujiwara, T, Sato, T & Ido, T 1991, 'An efficient synthesis of 2‐ [ carbonyl‐ ¹¹C]acetamido‐2‐deoxy‐D‐glucopyranose (N‐[carbonyl‐¹¹C]acetyl‐D‐glucosamine)', Journal of Labelled Compounds and Radiopharmaceuticals, vol. 29, no. 4, pp. 485-490. https://doi.org/10.1002/jlcr.2580290414

Tada, Masao ; Oikawa, Atsushi ; Iwata, Ren ; Sato, Kazunori ; Sugiyama, Hiroshi ; Kubota, Kazuo ; Ishiwata, Kiichi ; Takahashi, Hiromu ; Wakui, Akira ; Abe, Yoshinao ; Yamaguchi, Tatsuo ; Fujiwara, Takehiko ; Sato, Tachio ; Ido, Tatsuo. / An efficient synthesis of 2‐ [ carbonyl‐ ¹¹C]acetamido‐2‐deoxy‐D‐glucopyranose (N‐[carbonyl‐¹¹C]acetyl‐D‐glucosamine). In: Journal of Labelled Compounds and Radiopharmaceuticals. 1991 ; Vol. 29, No. 4. pp. 485-490.

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abstract = "A rapid chemical synthesis of 2‐[carbonyl‐11C]acetamido‐2‐deoxy‐D‐glucopyranose (N‐[carbonyl‐11C]acetyl‐D‐glucosamine) starting from [11C]carbon dioxide is described. The total time required for the synthesis, the radiochemical yield, and purity of the titled sugar are ca. 60 min, 49.5% (based on [carbonyl‐11C]acetic acid), and >98%, respectively.",

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AU - Oikawa, Atsushi

AU - Iwata, Ren

AU - Sato, Kazunori

AU - Sugiyama, Hiroshi

AU - Kubota, Kazuo

AU - Ishiwata, Kiichi

AU - Takahashi, Hiromu

AU - Wakui, Akira

AU - Abe, Yoshinao

AU - Yamaguchi, Tatsuo

AU - Fujiwara, Takehiko

AU - Sato, Tachio

AU - Ido, Tatsuo

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N2 - A rapid chemical synthesis of 2‐[carbonyl‐11C]acetamido‐2‐deoxy‐D‐glucopyranose (N‐[carbonyl‐11C]acetyl‐D‐glucosamine) starting from [11C]carbon dioxide is described. The total time required for the synthesis, the radiochemical yield, and purity of the titled sugar are ca. 60 min, 49.5% (based on [carbonyl‐11C]acetic acid), and >98%, respectively.

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