An efficient, one‐pot synthesis of 2‐deoxy‐2‐[18F]fluoroacetamido‐D‐glucopyranose (N‐[18F]fluoroacetyl‐D‐glucosamine), potential diagnostic imaging agent

Masao Tada, Atsushi Oikawa, Ren Iwata, Takehiko Fujiwara, Kazuo Kubota, Taiju Matsuzawa, Hiroshi Sugiyama, Tatsuo Ido, Kiichi Ishiwata, Tachio Sato

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    17 Citations (Scopus)


    A rapid, one‐pot synthesis of 2‐deoxy‐2‐[18F]fluoroacetamido‐D‐glucopyranose (N‐[18F]fluoroacetyl‐D‐glucosamine) (1) starting from [18F]fluoride and ethyl bromoacetate is described. The synthesis was accomplished by a combination of halogen exchange, alkaline hydrolysis, and condensation. [18F]Fluoride was produced by the 18O (p, n) 18F nuclear reaction using the cyclotron. The total synthesis time, the radiochemical yield, and purity of (1) are ca. 90 min, ca. 9.1%, and >98%, respectively. Sugar (1) showed the diagnostic tumor‐imaging activity.

    Original languageEnglish
    Pages (from-to)1317-1324
    Number of pages8
    JournalJournal of Labelled Compounds and Radiopharmaceuticals
    Issue number11
    Publication statusPublished - 1989 Nov

    ASJC Scopus subject areas

    • Analytical Chemistry
    • Biochemistry
    • Radiology Nuclear Medicine and imaging
    • Drug Discovery
    • Spectroscopy
    • Organic Chemistry

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