An efficient method for the alkynylation of oxiranes using alkynyl boranes

Masahiko Yamaguchi, Ichiro Hirao

Research output: Contribution to journalArticlepeer-review

466 Citations (Scopus)

Abstract

Alkynyl boranes, generated in situ from lithium acetylides and boron trifluoride etherate, were found to react with oxiranes under mild reaction conditions to afford β-hydroxyacetylenes in high yields.

Original languageEnglish
Pages (from-to)391-394
Number of pages4
JournalTetrahedron Letters
Volume24
Issue number4
DOIs
Publication statusPublished - 1983
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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