An efficient method for construction of tetrahydroisoquinoline skeleton via double cyclization process using ortho-vinylbenzaldehydes and amino alcohols: application to the synthesis of (S)-cryptostyline II

Kazuteru Umetsu, Naoki Asao

    Research output: Contribution to journalArticle

    20 Citations (Scopus)

    Abstract

    Thermal double cyclization reaction using ortho-vinylbenzaldehyde and 3-aminopropanols proceeded smoothly to give isoquinoline derivatives via 6π-azaelectrocyclization pathway. The method was applied to the efficient synthesis of (S)-cryptostyline II.

    Original languageEnglish
    Pages (from-to)2722-2725
    Number of pages4
    JournalTetrahedron Letters
    Volume49
    Issue number17
    DOIs
    Publication statusPublished - 2008 Apr 21

    Keywords

    • (S)-Cryptostyline II
    • 6π-Azaelectrocyclization
    • Double cyclization process
    • Tetrahydroisoquinoline

    ASJC Scopus subject areas

    • Biochemistry
    • Drug Discovery
    • Organic Chemistry

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