Abstract
Thermal double cyclization reaction using ortho-vinylbenzaldehyde and 3-aminopropanols proceeded smoothly to give isoquinoline derivatives via 6π-azaelectrocyclization pathway. The method was applied to the efficient synthesis of (S)-cryptostyline II.
| Original language | English |
|---|---|
| Pages (from-to) | 2722-2725 |
| Number of pages | 4 |
| Journal | Tetrahedron Letters |
| Volume | 49 |
| Issue number | 17 |
| DOIs | |
| Publication status | Published - 2008 Apr 21 |
Keywords
- (S)-Cryptostyline II
- 6π-Azaelectrocyclization
- Double cyclization process
- Tetrahydroisoquinoline
ASJC Scopus subject areas
- Biochemistry
- Drug Discovery
- Organic Chemistry
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Umetsu, K., & Asao, N. (2008). An efficient method for construction of tetrahydroisoquinoline skeleton via double cyclization process using ortho-vinylbenzaldehydes and amino alcohols: application to the synthesis of (S)-cryptostyline II. Tetrahedron Letters, 49(17), 2722-2725. https://doi.org/10.1016/j.tetlet.2008.02.152