TY - JOUR
T1 - An autopsy case of angioimmunoblastic T-cell lymphoma with a high content of epithelioid cells in the lymph node
T2 - Immunohistochemical and genomic analyses
AU - Morita, Kazumasa
AU - Matsumura, Yumi
AU - Kudo, Hitoshi
AU - Fujii, Kimio
AU - Tachibana, Takao
AU - Ohta, Keiji
AU - Kamoto, Toshiyuki
AU - Okamoto, Hiroyuki
AU - Yamabe, Hirohiko
AU - Imamura, Sadao
AU - Fukumoto, Manabu
PY - 1997/10
Y1 - 1997/10
N2 - A 79-year-old female developed red papulonodular eruptions on her extremities, facial erythema, generalized lymphadenopathy and high fever. Histopathology of an affected lymph node showed the features of angioimmunoblastic T-cell lymphoma with a high content of epithelioid cells. She died about two years after the onset despite therapy. Genomic Southern blotting and immunostaining of the lymph nodes were performed twice. In August of 1993, Southern blotting did not show any rearrangement of the immunoglobulin or the T-cell receptor (TCR) gene. Small or medium-sized lymphoid cells were positive for CD4 or CD8 (CD4:CD8=2:1). However, in September of 1994 (at autopsy), rearrangements of TCR Cβ1, Jβ2 and Jγ genes were observed. Small or medium-sized lymphoid cells were positive for CD4, but negative for CD8. Several large cells were positive for Latent Membrane Protein 1 (LMP1) of the Epstein-Barr virus (EBV). Our results proved that selective oligoclonal proliferation of tumor cells (probably CD4+) accompanied the disease progress.
AB - A 79-year-old female developed red papulonodular eruptions on her extremities, facial erythema, generalized lymphadenopathy and high fever. Histopathology of an affected lymph node showed the features of angioimmunoblastic T-cell lymphoma with a high content of epithelioid cells. She died about two years after the onset despite therapy. Genomic Southern blotting and immunostaining of the lymph nodes were performed twice. In August of 1993, Southern blotting did not show any rearrangement of the immunoglobulin or the T-cell receptor (TCR) gene. Small or medium-sized lymphoid cells were positive for CD4 or CD8 (CD4:CD8=2:1). However, in September of 1994 (at autopsy), rearrangements of TCR Cβ1, Jβ2 and Jγ genes were observed. Small or medium-sized lymphoid cells were positive for CD4, but negative for CD8. Several large cells were positive for Latent Membrane Protein 1 (LMP1) of the Epstein-Barr virus (EBV). Our results proved that selective oligoclonal proliferation of tumor cells (probably CD4+) accompanied the disease progress.
KW - Angioimmunoblastic
KW - EB virus
KW - Epithelioid cells
KW - Gene rearrangement
KW - T-cell lymphoma
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U2 - 10.1111/j.1346-8138.1997.tb02309.x
DO - 10.1111/j.1346-8138.1997.tb02309.x
M3 - Article
C2 - 9375463
AN - SCOPUS:9844229380
VL - 24
SP - 642
EP - 648
JO - Journal of Dermatology
JF - Journal of Dermatology
SN - 0385-2407
IS - 10
ER -