TY - JOUR
T1 - An anaphylactic shock case after hepatic arterial infusion of Zinostatin Stimalamer suspension improved by anti-histaminics
AU - Fukuhara, K.
AU - Suzuki, M.
AU - Unno, Michiaki
AU - Rikiyama, T.
AU - Sakamoto, N.
AU - Takeuchi, H.
AU - Uchiyama, T.
AU - Yamaki, T.
AU - Iwasashi, H.
AU - Kodama, H.
AU - Matsuno, S.
PY - 1997/9/22
Y1 - 1997/9/22
N2 - A 47-year-old man with hepatocellular carcinoma (HCC) at anterior and medial segment in the liver was treated with hepatic arterial infusion of Zinostatin Stimalamer-lipiodol suspension (SMANCS). After the 2nd infusion of SMANCS, the accumulation of liplodol in the tumor was not good (Grade II), so additional administration was undertaken at five-weeks intervals. His systolic blood pressure immediately decreased from 120 to 60 mmHg, and he had numbness of hands, shaking chills, sweating, chest pain and numerous urticaria-like red exanthema. In spite of treatment by anti-shock agents such as steroid and catecholamines, these symptoms did nor disappear, but antihistaminics greatly improved them without any serious side effects. Because of the remarkable effects of the antihistaminics and possibility of antibody production (IgE) after repeated infusions of high molecular SMANCS, this patient may have suffered anaphylactic shock caused by massive histamine release from mast cells.
AB - A 47-year-old man with hepatocellular carcinoma (HCC) at anterior and medial segment in the liver was treated with hepatic arterial infusion of Zinostatin Stimalamer-lipiodol suspension (SMANCS). After the 2nd infusion of SMANCS, the accumulation of liplodol in the tumor was not good (Grade II), so additional administration was undertaken at five-weeks intervals. His systolic blood pressure immediately decreased from 120 to 60 mmHg, and he had numbness of hands, shaking chills, sweating, chest pain and numerous urticaria-like red exanthema. In spite of treatment by anti-shock agents such as steroid and catecholamines, these symptoms did nor disappear, but antihistaminics greatly improved them without any serious side effects. Because of the remarkable effects of the antihistaminics and possibility of antibody production (IgE) after repeated infusions of high molecular SMANCS, this patient may have suffered anaphylactic shock caused by massive histamine release from mast cells.
KW - Anaphylactic shock
KW - Antihistaminics
KW - Zinostatin stimalamer
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M3 - Article
C2 - 9212813
AN - SCOPUS:0030848806
VL - 24
SP - 1023
EP - 1026
JO - Japanese Journal of Cancer and Chemotherapy
JF - Japanese Journal of Cancer and Chemotherapy
SN - 0385-0684
IS - 8
ER -