An analysis of potential surrogate markers of target-specific therapy in archival materials of adrenocortical carcinoma

Megumi Nakamura, Yasuhiro Miki, Jun Ichi Akahira, Ryo Morimoto, Fumitoshi Satoh, Shigeto Ishidoya, Yoichi Arai, Takashi Suzuki, Yutaka Hayashi, Hironobu Sasano

Research output: Contribution to journalArticlepeer-review

17 Citations (Scopus)


Adrenocortical carcinoma (ACC) is a rare neoplasm but some of the cases are highly malignant. Clinical outcome of the patients with advanced ACC still remained poor or dismal despite recent development of aggressive antitumor therapies. Target-specific therapies have been developed in a number of human malignancies and resulted in therapeutic benefits in some cancer patients. However, these therapies are only effective in the cases in which corresponding targets are expressed in tumor tissues. Therefore, we evaluated expression of potential surrogate markers using immunohistochemistry in archival materials of adrenocortical carcinoma in order to explore the potential application of target specific therapies in ACC in this study. We immunolocalized ten established or potential surrogate markers of target-specific therapies, located in the Ras/ extracellular signal-regulated kinase and phosphatidylinosi-tol-3 kinase/Akt pathways, in 41 ACC cases, 54 adreno-cortical adenoma (ACA) cases, and five nonpathological adrenal glands and correlated the findings with clinicopath-ological factors of the patients. Among these markers examined, only epidermal growth factor receptor (EGFR) was significantly more abundant in ACC than in ACA (P< 0.01). These findings suggest that the agents which specifically inhibit signal transductions through EGFR such as monoclonal antibodies against EGFR are considered to be worthwhile to be attempted in future clinical studies.

Original languageEnglish
Pages (from-to)17-23
Number of pages7
JournalEndocrine Pathology
Issue number1
Publication statusPublished - 2009 Mar


  • Adrenocortical carcinoma
  • EGFR
  • Immunohistochemistry
  • PI3K/Akt pathway
  • Ras/ERK pathway
  • Target-specific therapy

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology


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