An adsorption behavior of low-density lipoprotein onto cholesterol-modified dextran studied by a quartz crystal microbalance

Dongbo Liu, Bingjun He, Songyan Han, Shenqi Wang, Qingping Liu, Anzai Jun-ichi, Tetsuo Osa, Qiang Chen

Research output: Contribution to journalArticlepeer-review

13 Citations (Scopus)

Abstract

The use of quartz crystal microbalance (QCM) for on-line monitoring of the adsorption of low-density lipoprotein (LDL) onto cholesterol-modified dextran (CMD) was described. Kinetics studies were made and molecule interaction mechanism was discussed. Experimental results showed that kinetic curves fitted Langmuir adsorption equation quite well. When LDL concentrations (ng/μl) were 9.9, 12.38 and 14.14, respectively, the apparent rate constants (s- 1) and adsorption capacities (ng/cm2) were estimated to be 0.0477, 0.0536, 0.0628 and 124.5, 161.6, 194.3, respectively. The maximal LDL adsorption capacity attained 329.6 ng/cm2 and the adsorptive efficiency was calculated to be 72.91%. Moreover, a new method to evaluate the adsorption behavior was provided.

Original languageEnglish
Pages (from-to)665-669
Number of pages5
JournalMaterials Science and Engineering C
Volume27
Issue number4
DOIs
Publication statusPublished - 2007 May 16

Keywords

  • Adsorption
  • Cholesterol-modified dextran
  • Low-density lipoprotein
  • Quartz crystal microbalance

ASJC Scopus subject areas

  • Materials Science(all)
  • Condensed Matter Physics
  • Mechanics of Materials
  • Mechanical Engineering

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