An adaptive control system dependent on peripheral vascular resistance for a continuous-flow total artificial heart

T. Miura, M. Yoshizawa, A. Tanaka, K. Abe, T. Yambe, S. Nitta, Y. Abe, T. Chinzei, K. Imachi

Research output: Contribution to journalArticlepeer-review


To realize the physiological and adaptive cardiac output regulation of a pulsatile-flow total artificial heart (TAH), the authors have previously developed an adaptive control algorithm dependent on peripheral vascular resistance. In this study, it is discussed whether this algorithm can also be applied to a continuous-flow TAH. Our new algorithm for a continuous-flow TAH has been changed mainly in terms of the kind of controlled variables and the control time interval in relation to the algorithm previously used for a pulsatile-flow TAH. In our experiment, two small motor-driven centrifugal pumps were used to assess the proposed algorithm in a mock circulatory system with systemic and pulmonary circulations. It was revealed that the continuous-flow TAH controlled by the proposed algorithm was superior to air- driven pulsatile-flow TAH in terms of the quick and stable control characteristics, the simplicity of the algorithmic structure, and the reduced number of measurements. Moreover, it appears that the proposed algorithm can realize blood flow regulation similar to Abe's 1/R-control, which is a control strategy dependent on peripheral vascular resistance, and it is expected that our adaptive control mechanism will be able to overcome large differences among driving modes or the dynamic characteristics of pumps, individual difference and the time-varying characteristics of circulatory systems.

Original languageEnglish
Pages (from-to)394-399
Number of pages6
JournalJapanese Journal of Artificial Organs
Issue number2
Publication statusPublished - 1999


  • ARMA model
  • Adaptive control
  • Continuous-flow blood pump
  • Peripheral vascular resistance
  • Total artificial heart

ASJC Scopus subject areas

  • Biophysics


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