Amyloid β induces adhesion of erythrocytes to endothelial cells and affects endothelial viability and functionality

Kiyotaka Nakagawa, Takehiro Kiko, Satoko Kuriwada, Taiki Miyazawa, Fumiko Kimura, Teruo Miyazawa

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

It has been suggested that amyloid β-peptide (A β) might mediate the adhesion of erythrocytes to the endothelium which could disrupt the properties of endothelial cells. We provide evidence here that Aβactually induced the binding of erythrocytes to endothelial cells and decreased endothelial viability, perhaps by the generation of oxidative and inflammatory stress. These changes are likely to contribute to the pathogenesis of Alzheimer's disease.

Original languageEnglish
Pages (from-to)2030-2033
Number of pages4
JournalBioscience, Biotechnology and Biochemistry
Volume75
Issue number10
DOIs
Publication statusPublished - 2011

Keywords

  • Alzheimer's disease
  • Amyloid β-peptide
  • Endothelial cell
  • Red blood cell

ASJC Scopus subject areas

  • Biotechnology
  • Analytical Chemistry
  • Biochemistry
  • Applied Microbiology and Biotechnology
  • Molecular Biology
  • Organic Chemistry

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