Amyloid β-induced erythrocytic damage and its attenuation by carotenoids

Kiyotaka Nakagawa, Takehiro Kiko, Taiki Miyazawa, Phumon Sookwong, Tsuyoshi Tsuduki, Akira Satoh, Teruo Miyazawa

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

The presence of amyloid β-peptide (Aβ) in human blood has recently been established, and it has been hypothesized that Aβ readily contacts red blood cells (RBC) and oxidatively impairs RBC functions. In this study, we conducted in vitro and in vivo studies, which provide evidence that Aβ induces oxidative injury to RBC by binding to them, causing RBC phospholipid peroxidation and diminishing RBC endogenous carotenoids, especially xanthophylls. This type of damage is likely to injure the vasculature, potentially reducing oxygen delivery to the brain and facilitating Alzheimer's disease (AD). As a preventive strategy, because the Aβ-induced RBC damage could be attenuated by treatment of RBC with xanthophylls, we suggest that xanthophylls may contribute to the prevention of AD.

Original languageEnglish
Pages (from-to)1249-1254
Number of pages6
JournalFEBS Letters
Volume585
Issue number8
DOIs
Publication statusPublished - 2011 Apr 20

Keywords

  • Alzheimer's disease
  • Amyloid β-peptide
  • Erythrocyte
  • Oxidative injury
  • Phospholipid hydroperoxide

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

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