Ampelopsins E, E, H and cis-ampelopsin E, oligostilbenes from Ampelopsis brevipedunculata var. Hancei roots

Yoshiteru Oshima, Yuji Ueno

Research output: Contribution to journalArticlepeer-review

82 Citations (Scopus)

Abstract

The methanol extract of the roots of Ampelopsis brevipedunculata var. hancei exhibited marked protective activity against carbon tetrachloride and d-galactosamine-induced liver damage in primary cultured rat hepatocytes. The extract was fractionated by monitoring the activity to give active fractions from which four novel oxidative oligostilbenes, ampelopsins D, E, H and cis-ampelopsin E, were isolated in addition to the known compounds, (-)-epicatechin, pallidol, miyabenol C, piceid, cis-piceid and resveratroloside. The structures of the new stilbene derivatives have been established on the basis of spectroscopic evidence and chemical reactions. Among them, ampelopsin E and cis-ampelopsin E showed antihepatotoxic activity.

Original languageEnglish
Pages (from-to)179-182
Number of pages4
JournalPhytochemistry
Volume33
Issue number1
DOIs
Publication statusPublished - 1993 Apr 29

Keywords

  • Ampelopsis brevipedunculata
  • Vitaceae
  • ampelopsins D, E, H, cis-ampelopsin E
  • antihepatotoxic activity
  • oligostilbenes
  • primary cultured rat hepatocytes.
  • roots
  • wild vine

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Plant Science
  • Horticulture

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