TY - JOUR
T1 - Aminopeptidases and angiogenesis
AU - Sato, Yasufumi
N1 - Funding Information:
Received 25 July 2003; accepted 9 September 2003. The author acknowledges the support from the Japanese Ministry of Education, Science, Sports, and Culture, and from the Japan Society of the Promotion of Science Research for the Future. Address correspondence to Yasufumi Sato, Department of Vascular Biology, Institute of Development, Aging and Cancer, Tohoku University, Sendai 980-8575, Japan. E-mail: y-sato@idac.tohoku.ac.jp
PY - 2003
Y1 - 2003
N2 - A number of proteases, including matrix metalloproteinases and plasminogen activators, have been shown to be involved in angiogenesis. In addition, recent reports suggest that aminopeptidases also play roles in angiogenesis. These peptidases regulate the N-terminal modification of proteins and peptides required in processes such as maturation, activation, or degradation, and thereby they are related to a variety of physiological and pathological processes. At least three aminopeptidases are reported to be involved in angiogenesis, namely, type 2 methionine aminopeptidase, aminopeptidase N, and adipocyte-derived leucine aminopeptidase/puromycin-insensitive leucyl-specific aminopeptidase. This review will focus on the possible role of these aminopeptidases in angiogenesis.
AB - A number of proteases, including matrix metalloproteinases and plasminogen activators, have been shown to be involved in angiogenesis. In addition, recent reports suggest that aminopeptidases also play roles in angiogenesis. These peptidases regulate the N-terminal modification of proteins and peptides required in processes such as maturation, activation, or degradation, and thereby they are related to a variety of physiological and pathological processes. At least three aminopeptidases are reported to be involved in angiogenesis, namely, type 2 methionine aminopeptidase, aminopeptidase N, and adipocyte-derived leucine aminopeptidase/puromycin-insensitive leucyl-specific aminopeptidase. This review will focus on the possible role of these aminopeptidases in angiogenesis.
KW - Aminopeptidase
KW - Angiogenesis
KW - Endothelial cells
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U2 - 10.1080/10623320390272334
DO - 10.1080/10623320390272334
M3 - Review article
C2 - 14741843
AN - SCOPUS:1142299738
SN - 1062-3329
VL - 10
SP - 287
EP - 290
JO - Endothelium: Journal of Endothelial Cell Research
JF - Endothelium: Journal of Endothelial Cell Research
IS - 6
ER -