Aminopeptidases and angiogenesis

Research output: Contribution to journalReview article

25 Citations (Scopus)

Abstract

A number of proteases, including matrix metalloproteinases and plasminogen activators, have been shown to be involved in angiogenesis. In addition, recent reports suggest that aminopeptidases also play roles in angiogenesis. These peptidases regulate the N-terminal modification of proteins and peptides required in processes such as maturation, activation, or degradation, and thereby they are related to a variety of physiological and pathological processes. At least three aminopeptidases are reported to be involved in angiogenesis, namely, type 2 methionine aminopeptidase, aminopeptidase N, and adipocyte-derived leucine aminopeptidase/puromycin-insensitive leucyl-specific aminopeptidase. This review will focus on the possible role of these aminopeptidases in angiogenesis.

Original languageEnglish
Pages (from-to)287-290
Number of pages4
JournalEndothelium: Journal of Endothelial Cell Research
Volume10
Issue number6
DOIs
Publication statusPublished - 2003 Jan 1

Keywords

  • Aminopeptidase
  • Angiogenesis
  • Endothelial cells

ASJC Scopus subject areas

  • Physiology
  • Cell Biology

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