Aminoaldehyde-ene reaction: Stereoselective route to β-amino alcohols

Mikami Koichi, Kaneko Masami, Loh Teck-Peng, Terada Masahiro, Nakai Takeshi

Research output: Contribution to journalArticle

48 Citations (Scopus)

Abstract

The Lewis acid-promoted ene reactions with α-amino aldehydes as enophiles have been developed and shown to attain high level of syn-diastereofacial control, by the judicious choice of the amino-protecting group and the Lewis acid employed. The aldol-type reactions of ketene silyl acetals with α-amino aldehydes have also been developed to afford high level of either syn- or anti-diastereofacial control.

Original languageEnglish
Pages (from-to)3909-3912
Number of pages4
JournalTetrahedron Letters
Volume31
Issue number27
DOIs
Publication statusPublished - 1990
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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