Amino amide organocatalysts for asymmetric michael addition of β-Keto esters with β-nitroolefins

Isiaka Alade Owolabi, Madhu Chennapuram, Chigusa Seki, Yuko Okuyama, Eunsang Kwon, Koji Uwai, Michio Tokiwa, Mitsuhiro Takeshita, Hiroto Nakano

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

Asymmetric Michael addition of β-keto esters with trans-β-nitroolefins using chiral amino amide organocatalyst was tried and afforded synthetically useful chiral Michael adducts in both excellent chemical yields (up to 99%) and stereoselectivities (up to dr. 99:1, up to 98% ee).

Original languageEnglish
Pages (from-to)696-701
Number of pages6
JournalBulletin of the Chemical Society of Japan
Volume92
Issue number3
DOIs
Publication statusPublished - 2019

Keywords

  • Amino amide
  • Michael addition
  • Organocatalyst

ASJC Scopus subject areas

  • Chemistry(all)

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