Amadori-glycated phosphatidylethanolamine enhances the physical stability and selective targeting ability of liposomes

Taiki Miyazawa, Reina Kamiyoshihara, Naoki Shimizu, Takahiro Harigae, Yurika Otoki, Junya Ito, Shunji Kato, Teruo Miyazawa, Kiyotaka Nakagawa

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)

Abstract

Liposomes consisting of 100% phosphatidylcholine exhibit poor membrane fusion, cellular uptake and selective targeting capacities. To overcome these limitations, we used Amadori-glycated phosphatidylethanolamine, which is universally present in animals and commonly consumed in foods. We found that liposomes containing Amadori-glycated phosphatidylethanolamine exhibited significantly reduced negative membrane potential and demonstrated high cellular uptake.

Original languageEnglish
Article number171249
JournalRoyal Society Open Science
Volume5
Issue number2
DOIs
Publication statusPublished - 2018 Feb

Keywords

  • Amadori-glycated phosphatidylethanolamine
  • Curcumin
  • Glucose transporter
  • Glycolipid
  • Liposome
  • Maillard reaction product

ASJC Scopus subject areas

  • General

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