Alzheimer’s disease and type 2 diabetes mellitus: The use of mct oil and a ketogenic diet

Research output: Contribution to journalReview articlepeer-review

Abstract

Recently, type 2 diabetes mellitus (T2DM) has been reported to be strongly associated with Alzheimer’s disease (AD). This is partly due to insulin resistance in the brain. Insulin signaling and the number of insulin receptors may decline in the brain of T2DM patients, resulting in impaired synaptic formation, neuronal plasticity, and mitochondrial metabolism. In AD patients, hypometabolism of glucose in the brain is observed before the onset of symptoms. Amyloid-β accu-mulation, a main pathology of AD, also relates to impaired insulin action and glucose metabolism, although ketone metabolism is not affected. Therefore, the shift from glucose metabolism to ketone metabolism may be a reasonable pathway for neuronal protection. To promote ketone metabolism, medium-chain triglyceride (MCT) oil and a ketogenic diet could be introduced as an alternative source of energy in the brain of AD patients.

Original languageEnglish
Article number12310
JournalInternational journal of molecular sciences
Volume22
Issue number22
DOIs
Publication statusPublished - 2021 Nov 1

Keywords

  • Alzheimer’s disease
  • Amyloid-beta
  • Coconut oil
  • Glucose metabolism
  • Insulin resistance
  • Ketogenic diet
  • Ketone metabolism
  • MCT oil
  • Type 2 diabetes mellitus

ASJC Scopus subject areas

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

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