Alzheimer's amyloid precursor protein accumulates within axonal swellings in human brain lesions

Tetsuya Ohgami, Tetsuyuki Kitamoto, Jun Tateishi

Research output: Contribution to journalArticlepeer-review

63 Citations (Scopus)

Abstract

By using a monoclonal antibody and polyclonal antibodies to human β amyloid precursor protein (APP), we immunohistochemically examined axonal swellings (spheroids). The immunoreactivity of APP was observed in numerous spheroids, which were found around the areas of old cerebral infarctions, in the globus pallidus with Hallervorden-Spatz disease as well as in or around brain abscesses. The axonal swellings were not immunolabeled with β protein. These results implied that APP accumulated in spheroids regardless of β protein depositions.

Original languageEnglish
Pages (from-to)75-78
Number of pages4
JournalNeuroscience Letters
Volume136
Issue number1
DOIs
Publication statusPublished - 1992 Feb 17
Externally publishedYes

Keywords

  • Alzheimer's disease
  • Axonal swelling
  • Hallervorden-Spatz disease
  • Immunohistochemistry
  • Infarction
  • Spheroid
  • β Amyloid precursor protein
  • β Amyloid protein

ASJC Scopus subject areas

  • Neuroscience(all)

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