Abstract
Red-shifted channelrhodopsins (ChRs) are attractive for optogenetic tools. We developed a new type of red-shifted ChRs that utilized noncovalent incorporation of retinal and 3,4-dehydroretinal-based enamine-type Schiff bases and mutated channelopsin, C1C2-K296G. These ChRs exhibited absorption maxima that were shifted 10-30 nm toward longer wavelengths than that of C1C2-ChR regenerated with alltrans- retinal.
Original language | English |
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Pages (from-to) | 356-358 |
Number of pages | 3 |
Journal | Chemical and Pharmaceutical Bulletin |
Volume | 65 |
Issue number | 4 |
DOIs | |
Publication status | Published - 2017 |
Keywords
- Channelrhodopsin
- Chromophore
- Neuroscience
- Optogenetics
- Red-shift
ASJC Scopus subject areas
- Chemistry(all)
- Drug Discovery