Altering the microtubule kinesin nanomechanics in the presence of metallic ions

Sanjib Bhattacharyya, Kyongwan Kim, Hikaru Nakazawa, Mitsuo Umetsu, Winfried Teizer

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Microtubules play an important role in intraneuronal communication. A barrier to microtubule mediated neuronal transport can initiate dementia. The nanoscale modeling of these biological events is expected to be useful for healthcare applications and auxiliary biosensor based diagnostics. Here, we report a model system by using an in vitro bio-motility assay to predict events related to dementia at excess metal ion concentration. We demonstrate how metal ions (calcium, iron, zinc) at pathophysiologically relevant concentrations have the ability to affect the gliding motion of microtubules on kinesin. The addition of the neurotransmitter (acetyl choline) has no apparent effect on MT gliding. Therefore, the reagents that can stabilize the bio-motility system have potential to regulate dementia.

Original languageEnglish
Title of host publication16th International Conference on Nanotechnology - IEEE NANO 2016
PublisherInstitute of Electrical and Electronics Engineers Inc.
Pages79-81
Number of pages3
ISBN (Electronic)9781509039142
DOIs
Publication statusPublished - 2016 Nov 21
Event16th IEEE International Conference on Nanotechnology - IEEE NANO 2016 - Sendai, Japan
Duration: 2016 Aug 222016 Aug 25

Publication series

Name16th International Conference on Nanotechnology - IEEE NANO 2016

Other

Other16th IEEE International Conference on Nanotechnology - IEEE NANO 2016
CountryJapan
CitySendai
Period16/8/2216/8/25

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Atomic and Molecular Physics, and Optics

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    Bhattacharyya, S., Kim, K., Nakazawa, H., Umetsu, M., & Teizer, W. (2016). Altering the microtubule kinesin nanomechanics in the presence of metallic ions. In 16th International Conference on Nanotechnology - IEEE NANO 2016 (pp. 79-81). [7751410] (16th International Conference on Nanotechnology - IEEE NANO 2016). Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/NANO.2016.7751410