Altered plasma levels of cytokines in patients with ischemic heart disease

Hideki Tashiro, Hiroaki Shimokawa, Kunihiko Yamamoto, Michiko Momohara, Hideo Tada, Akira Takeshita

Research output: Contribution to journalArticle

60 Citations (Scopus)

Abstract

Background: Cytokines play an important role in mediating inflammatory-proliferative responses, including atherosclerosis. Alterations in the plasma levels of cytokines in patients with ischemic heart disease (IHD) remain to be examined. Objective: To examine the possible alterations in the plasma levels of cytokines in patients with IHD and in controls. Methods: Thirty-one patients with IHD and 16 controls were studied. The cytokines measured in our study included interleukin-6, macrophage-colony-stimulating factor (MCSF), transforming growth factor-β (TGF-β), and seven other major cytokines. The measurements were performed by using an enzyme-linked immunosorbent assay method. Results: The MCSF levels were significantly higher in patients with IHD than they were in controls (P < 0.01), whereas the TGF-β levels were significantly lower in patients with IHD than they were in controls (P < 0.01). Moreover, the levels of MCSF and those of TGF-β were correlated negatively (P < 0.05). The interleukin-6 levels tended to be higher in patients with unstable angina. The plasma levels of other cytokines were below the detection levels in most cases. Conclusions: Results from studies in vitro suggested that the process of atherosclerosis is accelerated and inhibited by MCSF and TGF-β, respectively. The present results thus suggest that the alterations in the plasma levels of MCSF and TGF-β may be involved in the pathogenesis of IHD in humans.

Original languageEnglish
Pages (from-to)143-147
Number of pages5
JournalCoronary Artery Disease
Volume8
Issue number3-4
Publication statusPublished - 1997 Jul 17
Externally publishedYes

Keywords

  • Cytokine
  • Ischemic heart disease
  • Macrophage colony-stimulating factor
  • Transforming growth factor-β
  • Unstable angina

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Fingerprint Dive into the research topics of 'Altered plasma levels of cytokines in patients with ischemic heart disease'. Together they form a unique fingerprint.

  • Cite this

    Tashiro, H., Shimokawa, H., Yamamoto, K., Momohara, M., Tada, H., & Takeshita, A. (1997). Altered plasma levels of cytokines in patients with ischemic heart disease. Coronary Artery Disease, 8(3-4), 143-147.