Altered mismatch response of inferior parietal lobule in amnestic mild cognitive impairment: A magnetoencephalographic study

Pin Yu Chen, Hui Yun Hsu, Yi Ping Chao, Rui Nouchi, Pei Ning Wang, Chia Hsiung Cheng

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)


Background: Mismatch negativity (MMN) reflects the functional integrity of sensory memory function. With the advantages of independence of individual's focused attention and behavioral cooperation, this neurophysiological signal is particularly suitable for investigating elderly with cognitive decline such as amnestic mild cognitive impairment (aMCI). However, the existing results remain substantially inconsistent whether these patients show deficits of MMN. In order to reconcile the previous disputes, the present study used magnetoencephalography combined with distributed source imaging methods to determine the source-level magnetic mismatch negativity (MMNm) in aMCI. Methods: A total of 26 healthy controls (HC) and 26 patients with aMCI underwent an auditory oddball paradigm during the MEG recordings. MMNm amplitudes and latencies in the bilateral superior temporal gyrus, inferior frontal gyrus, and inferior parietal lobule (IPL) were compared between HC and aMCI groups. The correlations of MMNm responses with performance of auditory/verbal memory tests were examined. Finally, MMNm and its combination with verbal/auditory memory tests were submitted to receiver operating characteristic (ROC) curve analysis. Results: Compared to HC, patients with aMCI showed significantly delayed MMNm latencies in the IPL. Among the patients with aMCI, longer MMNm latencies of left IPL were associated with lower scores of Chinese Version Verbal Learning Test (CVVLT). The ROC curve analysis revealed that the combination of MMNm latencies of left IPL and CVVLT scores yielded a moderate accuracy in the discrimination of aMCI from HC at an individual level. Conclusions: Our data suggest dysfunctional MMNm in patients with aMCI, particularly in the IPL.

Original languageEnglish
Pages (from-to)1136-1145
Number of pages10
JournalCNS Neuroscience and Therapeutics
Issue number10
Publication statusPublished - 2021 Oct


  • amnestic mild cognitive impairment (aMCI)
  • inferior parietal lobule (IPL)
  • magnetoencephalography (MEG)
  • mismatch negativity (MMN)

ASJC Scopus subject areas

  • Pharmacology
  • Psychiatry and Mental health
  • Physiology (medical)
  • Pharmacology (medical)


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