Altered endogenous negativities of the visual event-related potential in remitted schizophrenia

Hiroo Matsuoka, Hidemitsu Saito, Takashi Ueno, Mitsumoto Sato

Research output: Contribution to journalArticlepeer-review

19 Citations (Scopus)


Visual event-related potentials (ERPs) were recorded during a simple response task (SRT) and a discriminative response task (DRT) in remitted schizophrenic outpatients and age-matched controls to examine 2 endogenous negative potentials: NA and N2c. The NA potentials were derived by subtracting the ERPs for SRT from those for non-target stimuli in DRT. Other subtracting wave forms, N2c potentials, were calculated as the difference between ERPs for target and non-target stimuli-in DRT. Schizophrenics showed retardation in NA and N2c peaks and degradation in N2c amplitude relative to controls. The NA peak latency increased as much as the latencies of N2c and reaction time for DRT in schizophrenia. The NA peak emerged prior to the N2c peak, while the NA peak latency correlated closely with the N2c latency. These results indicate that the retarded NA peak latency may serve as a physiological marker for neurobiological vulnerability of schizophrenia.

Original languageEnglish
Pages (from-to)18-24
Number of pages7
JournalElectroencephalography and Clinical Neurophysiology - Evoked Potentials
Issue number1
Publication statusPublished - 1996


  • Endogenous negativity
  • Event-related potential
  • N2
  • NA
  • Schizophrenia
  • Vulnerability

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology


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