Altered developmental events in the anterior region of the chick forelimb give rise to avian-specific digit loss

Naoki Nomura, Hitoshi Yokoyama, Koji Tamura

    Research output: Contribution to journalArticlepeer-review

    4 Citations (Scopus)

    Abstract

    Background: Avian forelimb (wing) contains only three digits, and the three-digit formation in the bird forelimb is one of the avian-specific limb characteristics that have been evolutionarily inherited from the common ancestral form in dinosaurs. Despite many studies on digit formation in the chick limb bud, the developmental mechanisms giving rise to the three-digit forelimb in birds have not been completely clarified. Results: To identify which cell populations of the early limb bud contribute to digit formation in the late limb bud, fate maps of the early fore- and hindlimb buds were prepared. Based on these fate maps, we found that the digit-forming region in the forelimb bud is narrower than that in the hindlimb bud, suggesting that some developmental mechanisms on the anterior-most region lead to a reduced number of digits in the forelimb. We also found temporal differences in the onset of appearance of the ANZ (anterior necrotic zone) as well as differences in the position of the anterior edge of the AER. Conclusions: Forelimb-specific events in the anterior limb bud are possible developmental mechanisms that might generate the different cell fates in the fore- and hindlimb buds, regulating the number of digits in birds.

    Original languageEnglish
    Pages (from-to)741-752
    Number of pages12
    JournalDevelopmental Dynamics
    Volume243
    Issue number6
    DOIs
    Publication statusPublished - 2014 Jun

    Keywords

    • Apical ectodermal ridge
    • Apoptosis
    • Bird
    • Fate map
    • Wing

    ASJC Scopus subject areas

    • Developmental Biology

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