Altered cytokine activities are related to the suppression of synthesis of normal immunoglobulin in multiple myeloma

Michio Kawano, Koji Iwato, Hideki Asaoku, Osamu Tanabe, Hideo Tanaka, Hideaki Ishikawa, Atsushi Kuramoto

Research output: Contribution to journalArticlepeer-review

15 Citations (Scopus)

Abstract

The content of peripheral blood B cells (B1+) was reduced in patients of multiple myeloma (MM) and not in those with benign monoclonal gammopathy (BMG) compared to normal donors (P < 0.01). This observation correlated with the suppression of synthesis of normal immunoglobulin (Ig) in MM. Thus, cytokine activities regulating the proliferation of normal mature B cells, such as B cell stimulatory factor 1 (BSF‐1)/ inlerleukin 4 (IL‐4), B cell growth inhibitory factor (BIF) and IL‐2 in peripheral blood T cells, and IL‐1 in peripheral blood adherent cells, were investigated in patients with BMG (n ‐ 7) and MM (n = 28). All patients of MM having a marked suppression of synthesis of all other normal Ig, had significantly lower levels of BSF‐1 activity and inversely higher levels of BIF activity than those of normal donors. However, patients with BMG having no suppression of synthesis of normal Ig had BSF‐1 and BIF activities similar to normal donors. There was no significant difference in IL‐1 and fL‐2 activities between both normal donors and BMG versus MM patients. These data show that in MM altered cytokine activities correlate with suppression of synthesis of normal Ig.

Original languageEnglish
Pages (from-to)91-96
Number of pages6
JournalAmerican Journal of Hematology
Volume30
Issue number2
DOIs
Publication statusPublished - 1989 Feb

Keywords

  • benign monoclonal gammopathy
  • immunoglbulin synthesis
  • multiple myeloma

ASJC Scopus subject areas

  • Hematology

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