Alteration of white matter MR signal intensity in frontotemporal dementia

Hajime Kitagaki, Etsuro Mori, Nobutsugu Hirono, Yoshitaka Ikejiri, Kazunari Ishii, Toru Imamura, Manabu Ikeda, Shigeru Yamaji, Hikari Yamashita, Tatsuo Shimomura, Yoshitsugu Nakagawa

Research output: Contribution to journalArticlepeer-review

43 Citations (Scopus)


PURPOSE: To determine the diagnostic potential of MR imaging to show white matter involvement in frontotemporal dementia. METHODS: We evaluated MR signal intensity in cerebral white matter by visually inspecting and by quantitatively measuring signal intensity on MR images in 22 patients with frontotemporal dementia. The findings were compared with those in 22 age- and sex-matched patients who had had Alzheimer disease for the same length of time and with 16 age- and sex-matched healthy control subjects. RESULTS: Patients with frontotemporal dementia had a significant increase in white matter signal intensity in the frontal and/or temporal lobes on T2- and proton density-weighted images. Visual inspection of regular proton density- weighted images and measurements made on the T2- and proton density-weighted images were sensitive to changes in white matter signal. CONCLUSION: Increased MR signal intensity in the frontotemporal white matter on T2- and proton density-weighted MR images is a useful diagnostic sign of frontotemporal dementia and distinguishes this condition from Alzheimer disease.

Original languageEnglish
Pages (from-to)367-378
Number of pages12
JournalAmerican Journal of Neuroradiology
Issue number2
Publication statusPublished - 1997 Feb 27


  • Brain, magnetic resonance
  • Degenerative disease
  • Dementia

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Clinical Neurology


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