Alteration of regional cerebral glucose utilization with delusions in Alzheimer's disease

Nobutsugu Hirono; Etsuro Mori; Kazunari Ishii; Hajime Kitagaki; Masahiro Sasaki; Yoshitaka Ikejiri; Toru Imamura; Tatsuo Shimomura; Manabu Ikeda; Hikari Yamashita

doi:10.1176/jnp.10.4.433

Alteration of regional cerebral glucose utilization with delusions in Alzheimer's disease

Nobutsugu Hirono, Etsuro Mori, Kazunari Ishii, Hajime Kitagaki, Masahiro Sasaki, Yoshitaka Ikejiri, Toru Imamura, Tatsuo Shimomura, Manabu Ikeda, Hikari Yamashita

MED - Disability Science

Research output: Contribution to journal › Article › peer-review

57 Citations (Scopus)

Abstract

The authors examined 65 patients with Alzheimer's disease for delusions and explored the relationship of delusions with regional cerebral glucose metabolism determined by [¹⁸F]fluorodeoxyglucose PET. In patients with delusions (n = 26), normalized glucose metabolism was significantly increased in the left inferior temporal gyrus and significantly decreased in the left medial occipital region as compared with those without delusions (n = 39). The two groups were similar in age, sex, and dementia severity. These results suggest that delusions in Alzheimer's disease are attributable to a dysfunction in specific brain areas rather than a simple reaction to intellectual deficits.

Original language	English
Pages (from-to)	433-439
Number of pages	7
Journal	Journal of Neuropsychiatry and Clinical Neurosciences
Volume	10
Issue number	4
DOIs	https://doi.org/10.1176/jnp.10.4.433
Publication status	Published - 1998 Jan 1

ASJC Scopus subject areas

Clinical Neurology
Psychiatry and Mental health

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1176/jnp.10.4.433

Cite this

@article{e30765aed909441eb17be12517c1f14a,

title = "Alteration of regional cerebral glucose utilization with delusions in Alzheimer's disease",

abstract = "The authors examined 65 patients with Alzheimer's disease for delusions and explored the relationship of delusions with regional cerebral glucose metabolism determined by [18F]fluorodeoxyglucose PET. In patients with delusions (n = 26), normalized glucose metabolism was significantly increased in the left inferior temporal gyrus and significantly decreased in the left medial occipital region as compared with those without delusions (n = 39). The two groups were similar in age, sex, and dementia severity. These results suggest that delusions in Alzheimer's disease are attributable to a dysfunction in specific brain areas rather than a simple reaction to intellectual deficits.",

author = "Nobutsugu Hirono and Etsuro Mori and Kazunari Ishii and Hajime Kitagaki and Masahiro Sasaki and Yoshitaka Ikejiri and Toru Imamura and Tatsuo Shimomura and Manabu Ikeda and Hikari Yamashita",

year = "1998",

month = jan,

day = "1",

doi = "10.1176/jnp.10.4.433",

language = "English",

volume = "10",

pages = "433--439",

journal = "Journal of Neuropsychiatry and Clinical Neurosciences",

issn = "0895-0172",

publisher = "American Psychiatric Publishing Inc.",

number = "4",

}

TY - JOUR

T1 - Alteration of regional cerebral glucose utilization with delusions in Alzheimer's disease

AU - Hirono, Nobutsugu

AU - Mori, Etsuro

AU - Ishii, Kazunari

AU - Kitagaki, Hajime

AU - Sasaki, Masahiro

AU - Ikejiri, Yoshitaka

AU - Imamura, Toru

AU - Shimomura, Tatsuo

AU - Ikeda, Manabu

AU - Yamashita, Hikari

PY - 1998/1/1

Y1 - 1998/1/1

N2 - The authors examined 65 patients with Alzheimer's disease for delusions and explored the relationship of delusions with regional cerebral glucose metabolism determined by [18F]fluorodeoxyglucose PET. In patients with delusions (n = 26), normalized glucose metabolism was significantly increased in the left inferior temporal gyrus and significantly decreased in the left medial occipital region as compared with those without delusions (n = 39). The two groups were similar in age, sex, and dementia severity. These results suggest that delusions in Alzheimer's disease are attributable to a dysfunction in specific brain areas rather than a simple reaction to intellectual deficits.

AB - The authors examined 65 patients with Alzheimer's disease for delusions and explored the relationship of delusions with regional cerebral glucose metabolism determined by [18F]fluorodeoxyglucose PET. In patients with delusions (n = 26), normalized glucose metabolism was significantly increased in the left inferior temporal gyrus and significantly decreased in the left medial occipital region as compared with those without delusions (n = 39). The two groups were similar in age, sex, and dementia severity. These results suggest that delusions in Alzheimer's disease are attributable to a dysfunction in specific brain areas rather than a simple reaction to intellectual deficits.

UR - http://www.scopus.com/inward/record.url?scp=0031730229&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0031730229&partnerID=8YFLogxK

U2 - 10.1176/jnp.10.4.433

DO - 10.1176/jnp.10.4.433

M3 - Article

C2 - 9813789

AN - SCOPUS:0031730229

VL - 10

SP - 433

EP - 439

JO - Journal of Neuropsychiatry and Clinical Neurosciences

JF - Journal of Neuropsychiatry and Clinical Neurosciences

SN - 0895-0172

IS - 4

ER -

Alteration of regional cerebral glucose utilization with delusions in Alzheimer's disease

Abstract

ASJC Scopus subject areas

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this