Alteration of regional cerebral glucose utilization with delusions in Alzheimer's disease

Nobutsugu Hirono; Etsuro Mori; Kazunari Ishii; Hajime Kitagaki; Masahiro Sasaki; Yoshitaka Ikejiri; Toru Imamura; Tatsuo Shimomura; Manabu Ikeda; Hikari Yamashita

doi:10.1176/jnp.10.4.433

Alteration of regional cerebral glucose utilization with delusions in Alzheimer's disease

Nobutsugu Hirono, Etsuro Mori, Kazunari Ishii, Hajime Kitagaki, Masahiro Sasaki, Yoshitaka Ikejiri, Toru Imamura, Tatsuo Shimomura, Manabu Ikeda, Hikari Yamashita

MED - Disability Science

Research output: Contribution to journal › Article › peer-review

52 Citations (Scopus)

Abstract

The authors examined 65 patients with Alzheimer's disease for delusions and explored the relationship of delusions with regional cerebral glucose metabolism determined by [¹⁸F]fluorodeoxyglucose PET. In patients with delusions (n = 26), normalized glucose metabolism was significantly increased in the left inferior temporal gyrus and significantly decreased in the left medial occipital region as compared with those without delusions (n = 39). The two groups were similar in age, sex, and dementia severity. These results suggest that delusions in Alzheimer's disease are attributable to a dysfunction in specific brain areas rather than a simple reaction to intellectual deficits.

Original language	English
Pages (from-to)	433-439
Number of pages	7
Journal	Journal of Neuropsychiatry and Clinical Neurosciences
Volume	10
Issue number	4
DOIs	https://doi.org/10.1176/jnp.10.4.433
Publication status	Published - 1998 Jan 1

ASJC Scopus subject areas

Clinical Neurology
Psychiatry and Mental health

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Alteration of regional cerebral glucose utilization with delusions in Alzheimer's disease. / Hirono, Nobutsugu; Mori, Etsuro; Ishii, Kazunari; Kitagaki, Hajime; Sasaki, Masahiro; Ikejiri, Yoshitaka; Imamura, Toru; Shimomura, Tatsuo; Ikeda, Manabu; Yamashita, Hikari.

In: Journal of Neuropsychiatry and Clinical Neurosciences, Vol. 10, No. 4, 01.01.1998, p. 433-439.

Research output: Contribution to journal › Article › peer-review

Hirono, Nobutsugu ; Mori, Etsuro ; Ishii, Kazunari ; Kitagaki, Hajime ; Sasaki, Masahiro ; Ikejiri, Yoshitaka ; Imamura, Toru ; Shimomura, Tatsuo ; Ikeda, Manabu ; Yamashita, Hikari. / Alteration of regional cerebral glucose utilization with delusions in Alzheimer's disease. In: Journal of Neuropsychiatry and Clinical Neurosciences. 1998 ; Vol. 10, No. 4. pp. 433-439.

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