Alteration of regional cerebral glucose utilization with delusions in Alzheimer's disease

Nobutsugu Hirono, Etsuro Mori, Kazunari Ishii, Hajime Kitagaki, Masahiro Sasaki, Yoshitaka Ikejiri, Toru Imamura, Tatsuo Shimomura, Manabu Ikeda, Hikari Yamashita

Research output: Contribution to journalArticlepeer-review

57 Citations (Scopus)


The authors examined 65 patients with Alzheimer's disease for delusions and explored the relationship of delusions with regional cerebral glucose metabolism determined by [18F]fluorodeoxyglucose PET. In patients with delusions (n = 26), normalized glucose metabolism was significantly increased in the left inferior temporal gyrus and significantly decreased in the left medial occipital region as compared with those without delusions (n = 39). The two groups were similar in age, sex, and dementia severity. These results suggest that delusions in Alzheimer's disease are attributable to a dysfunction in specific brain areas rather than a simple reaction to intellectual deficits.

Original languageEnglish
Pages (from-to)433-439
Number of pages7
JournalJournal of Neuropsychiatry and Clinical Neurosciences
Issue number4
Publication statusPublished - 1998 Jan 1

ASJC Scopus subject areas

  • Clinical Neurology
  • Psychiatry and Mental health


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