TY - JOUR
T1 - Alteration of regional cerebral glucose utilization with delusions in Alzheimer's disease
AU - Hirono, Nobutsugu
AU - Mori, Etsuro
AU - Ishii, Kazunari
AU - Kitagaki, Hajime
AU - Sasaki, Masahiro
AU - Ikejiri, Yoshitaka
AU - Imamura, Toru
AU - Shimomura, Tatsuo
AU - Ikeda, Manabu
AU - Yamashita, Hikari
PY - 1998/1/1
Y1 - 1998/1/1
N2 - The authors examined 65 patients with Alzheimer's disease for delusions and explored the relationship of delusions with regional cerebral glucose metabolism determined by [18F]fluorodeoxyglucose PET. In patients with delusions (n = 26), normalized glucose metabolism was significantly increased in the left inferior temporal gyrus and significantly decreased in the left medial occipital region as compared with those without delusions (n = 39). The two groups were similar in age, sex, and dementia severity. These results suggest that delusions in Alzheimer's disease are attributable to a dysfunction in specific brain areas rather than a simple reaction to intellectual deficits.
AB - The authors examined 65 patients with Alzheimer's disease for delusions and explored the relationship of delusions with regional cerebral glucose metabolism determined by [18F]fluorodeoxyglucose PET. In patients with delusions (n = 26), normalized glucose metabolism was significantly increased in the left inferior temporal gyrus and significantly decreased in the left medial occipital region as compared with those without delusions (n = 39). The two groups were similar in age, sex, and dementia severity. These results suggest that delusions in Alzheimer's disease are attributable to a dysfunction in specific brain areas rather than a simple reaction to intellectual deficits.
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U2 - 10.1176/jnp.10.4.433
DO - 10.1176/jnp.10.4.433
M3 - Article
C2 - 9813789
AN - SCOPUS:0031730229
VL - 10
SP - 433
EP - 439
JO - Journal of Neuropsychiatry and Clinical Neurosciences
JF - Journal of Neuropsychiatry and Clinical Neurosciences
SN - 0895-0172
IS - 4
ER -