Alteration of hepatic sulfation by endotoxin

Miki Shimada, Eriko Watanabe, Yuka Iida, Kiyoshi Nagata, Yasushi Yamazoe

    Research output: Contribution to journalArticlepeer-review

    8 Citations (Scopus)

    Abstract

    Administration of an endotoxin, lipopolysaccharide (1 mg/kg body weight), caused decreases in hepatic sulfations of xenobiotics in male rats through changes in the amounts of at least three forms of sulfotransferases, ST1A1, ST1B1 and ST1C1. The time-dependent decrease was first observed with ST1B1, followed by ST1A1 and ST1C1; and the decrease was more profound in the levels of mRNAs than those of proteins. The decreases in their mRNAs were, however, prevented by the pretreatment with dexamethasone. These results suggest that the endotoxin suppresses the hepatic sulfation through a cytokine-mediated mechanism to change individually hepatic levels of ST1A1, ST1B1 and ST1C1.

    Original languageEnglish
    Pages (from-to)371-373
    Number of pages3
    JournalJapanese Journal of Pharmacology
    Volume80
    Issue number4
    DOIs
    Publication statusPublished - 1999

    Keywords

    • Lipopolysaccharide
    • Liver
    • Sulfotransferase

    ASJC Scopus subject areas

    • Pharmacology

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