Alteration of genome structure induced by very low dose-rate irradiation in mouse tissues

Tetsuya Ono, Yoshihiko Uehara, Naohito Okudaira, Kazuo Fujikawa, Nao Kagawa, Mitsuaki Yoshida, Isamu Hayata, Takehiko Nohmi, Tsuneya Matsumoto, Yoichi Oghiso, Kimio Tanaka, Kazuaki Ichinohe, Shingo Nakamura, Satoshi Tanaka

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

To understand the effects of low dose-rate radiation on genome structure in vivo, we examined gene mutation and chromosomal abnormality in mouse tissues. The mutation was studied on transgenes in the spleen and liver and also on the Dlb1 gene in intestinal stem cells. The mice were irradiated for 483 consecutive days at three dose-rates of 0.0323, 0.65, and 12.5 μGy/min, which resulted in total doses of 21, 414, and 8,000 mGy, respectively. Statistically significant increases were observed for all indices examined when the total dose was 8,000 mGy, whereas no significant difference was observed with 21 mGy or 414 mGy.

Original languageEnglish
Pages (from-to)BR36-BR41
JournalData Science Journal
Volume8
DOIs
Publication statusPublished - 2009 Sep 24

Keywords

  • Chromosomal abnormality
  • Low dose-rate
  • Mouse
  • Mutation
  • Radiation

ASJC Scopus subject areas

  • Computer Science (miscellaneous)
  • Computer Science Applications

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