Alteration of cystatin C in the cerebrospinal fluid of multiple sclerosis

Ichiro Nakashima, Masakatsu Fujinoki, Kazuo Fujihara, Takeshi Kawamura, Toshihide Nishimura, Masashi Nakamura, Yasuto Itoyama

Research output: Contribution to journalArticlepeer-review

23 Citations (Scopus)


The protein profiles in the cerebrospinal fluid of 10 patients with multiple sclerosis (MS), 10 patients with neuromyelitis optica (NMO), 8 inflammatory disease control patients, and 4 noninflammatory disease control patients were screened by surface-enhanced laser desorption/ionization time-of-flight mass spectrometry. Peaks of 12.5kDa were significantly lower in multiple sclerosis, NMO, and inflammatory disease control patients than in noninflammatory disease control patients, and 13.4kDa peaks were higher in NMO than in inflammatory disease control patients. Further analyses demonstrated that both peaks were cystatin C. Enzyme-linked immunosorbent assay showed that the cystatin C levels tended to be lower in multiple sclerosis and NMO. Alterations of cystatin C may relate to the pathogeneses of demyelinating diseases.

Original languageEnglish
Pages (from-to)197-200
Number of pages4
JournalAnnals of Neurology
Issue number2
Publication statusPublished - 2007 Aug 1

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology


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